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Title | Structural insights into the classification of Mud Crab Reovirus. |
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Journal, issue, pages | Virus Res, Vol. 166, Issue 1-2, Page 116-120, Year 2012 |
Publish date | Mar 6, 2012 |
Authors | Zengwei Huang / Xiexiong Deng / Yinyin Li / Hongjun Su / Kunpeng Li / Zhixun Guo / Peirui Zheng / Haidong Xu / Jianguo He / Qinfen Zhang / Shaoping Weng / |
PubMed Abstract | Cryo-electron microscopy was applied to analyze mud crab reovirus (MCRV), which causes 'sleeping disease' in mud crab, Scylla serrata, a marine species cultured in China. We present here the three ...Cryo-electron microscopy was applied to analyze mud crab reovirus (MCRV), which causes 'sleeping disease' in mud crab, Scylla serrata, a marine species cultured in China. We present here the three dimensional structure of MCRV at 13.8Å resolution. The outer capsid shell is composed of 260 trimers with complete T=13 icosahedral symmetry. A major difference between MCRV and previously reported aquareoviruses is that it lacks a pentameric turret structure. These results together with recently published molecular biological evidence (Deng et al., 2012) indicate that, from a structural perspective, MCRV should be classified as a new member of the family Reoviridae. |
External links | Virus Res / PubMed:22421382 |
Methods | EM (single particle) |
Resolution | 13.8 Å |
Structure data | EMDB-2054: |