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TitleThe EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.
Journal, issue, pagesEMBO J, Vol. 26, Issue 19, Page 4283-4291, Year 2007
Publish dateOct 3, 2007
AuthorsElena Yakubovskaya / Mark Lukin / Zhixin Chen / John Berriman / Joseph S Wall / Ryuji Kobayashi / Caroline Kisker / Daniel F Bogenhagen /
PubMed AbstractWe used electron microscopy to examine the structure of human DNA pol gamma, the heterotrimeric mtDNA replicase implicated in certain mitochondrial diseases and aging models. Separate analysis of ...We used electron microscopy to examine the structure of human DNA pol gamma, the heterotrimeric mtDNA replicase implicated in certain mitochondrial diseases and aging models. Separate analysis of negatively stained preparations of the catalytic subunit, pol gammaA, and of the holoenzyme including a dimeric accessory factor, pol gammaB(2), permitted unambiguous identification of the position of the accessory factor within the holoenzyme. The model explains protection of a partial chymotryptic cleavage site after residue L(549) of pol gammaA upon binding of the accessory subunit. This interaction region is near residue 467 of pol gammaA, where a disease-related mutation has been reported to impair binding of the B subunit. One pol gammaB subunit dominates contacts with the catalytic subunit, while the second B subunit is largely exposed to solvent. A model for pol gamma is discussed that considers the effects of known mutations in the accessory subunit and the interaction of the enzyme with DNA.
External linksEMBO J / PubMed:17762861 / PubMed Central
MethodsEM (single particle)
Resolution17.0 Å
Structure data

EMDB-1409:
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.
Method: EM (single particle) / Resolution: 17.0 Å

EMDB-1410:
The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.
Method: EM (single particle) / Resolution: 17.0 Å

Source
  • Homo sapiens (human)

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