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Structure paper

TitleStructure of the merozoite surface protein 1 from .
Journal, issue, pagesSci Adv, Vol. 7, Issue 23, Year 2021
Publish dateJun 2, 2021
AuthorsPatricia M Dijkman / Tanja Marzluf / Yingyi Zhang / Shih-Ying Scott Chang / Dominic Helm / Michael Lanzer / Hermann Bujard / Mikhail Kudryashev /
PubMed AbstractThe merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, ...The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in infection and immunity.
External linksSci Adv / PubMed:34078606
MethodsEM (single particle)
Resolution3.1 - 3.6 Å
Structure data

11150

6zbc

EMDB-11150, PDB-6zbc:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, main conformation
Method: EM (single particle) / Resolution: 3.1 Å

11151

6zbd

EMDB-11151, PDB-6zbd:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 2
Method: EM (single particle) / Resolution: 3.21 Å

11152

6zbe

EMDB-11152, PDB-6zbe:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 1
Method: EM (single particle) / Resolution: 3.3 Å

11153

6zbf

EMDB-11153, PDB-6zbf:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 3
Method: EM (single particle) / Resolution: 3.2 Å

11154

6zbg

EMDB-11154, PDB-6zbg:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 4
Method: EM (single particle) / Resolution: 3.2 Å

11155

6zbh

EMDB-11155, PDB-6zbh:
Merozoite surface protein 1 (MSP-1) from Plasmodium falciparum, alternative conformation 5
Method: EM (single particle) / Resolution: 3.6 Å

11156

6zbj

EMDB-11156, PDB-6zbj:
Plasmodium falciparum merozoite surface protein 1 dimer, conformation 1
Method: EM (single particle) / Resolution: 3.3 Å

11157

6zbl

EMDB-11157, PDB-6zbl:
Plasmodium falciparum merozoite surface protein 1 dimer, conformation 2
Method: EM (single particle) / Resolution: 3.6 Å

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsMEMBRANE PROTEIN / Merozoite surface protein 1 / malaria / Plasmodium falciparum / MSP-1 / p190 / GPI-anchored membrane protein

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