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-Structure paper
タイトル | Structure of a yeast 40S-eIF1-eIF1A-eIF3-eIF3j initiation complex. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 22, Issue 3, Page 269-271, Year 2015 |
掲載日 | 2015年2月9日 |
著者 | Christopher H S Aylett / Daniel Boehringer / Jan P Erzberger / Tanja Schaefer / Nenad Ban / |
PubMed 要旨 | Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing ...Eukaryotic translation initiation requires cooperative assembly of a large protein complex at the 40S ribosomal subunit. We have resolved a budding yeast initiation complex by cryo-EM, allowing placement of prior structures of eIF1, eIF1A, eIF3a, eIF3b and eIF3c. Our structure highlights differences in initiation-complex binding to the ribosome compared to that of mammalian eIF3, demonstrates a direct contact between eIF3j and eIF1A and reveals the network of interactions between eIF3 subunits. |
リンク | Nat Struct Mol Biol / PubMed:25664723 |
手法 | EM (単粒子) |
解像度 | 6.47 Å |
構造データ | |
化合物 | ChemComp-ZN: |
由来 |
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キーワード | TRANSLATION (翻訳 (生物学)) / EIF3 (EIF3) / TRANSLATION INITIATION |