タイトル | Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues. |
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ジャーナル・号・ページ | Chemmedchem, Vol. 9, Page 2286-2293, Year 2014 |
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掲載日 | 2013年4月11日 (構造データの登録日) |
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著者 | Pereira, J.H. / Petchprayoon, C. / Hoepker, A.C. / Moriarty, N.W. / Fink, S.J. / Cecere, G. / Paterson, I. / Adams, P.D. / Marriott, G. |
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リンク | Chemmedchem / PubMed:25047814 |
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手法 | X線回折 |
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解像度 | 1.4 - 2.9 Å |
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構造データ | PDB-4k41: Crystal structure of actin in complex with marine macrolide kabiramide C 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-4k42: Crystal structure of actin in complex with synthetic AplC tail analogue SF01 [(3R,4S,5R,6S,10R,11R,12R)-11-(acetyloxy)-1-(benzyloxy)-14-[formyl(methyl)amino]-5-hydroxy-4,6,10,12-tetramethyl-9-oxotetradecan-3-yl propanoate] 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-4k43: Crystal structure of actin in complex with synthetic AplC tail analogue GC04 [N-{(1E,4R,5R,7E,9S,10S,11S)-4,10-dimethoxy-11-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-5,9-dimethyl-6-oxododeca-1,7-dien-1-yl}-N-methylformamide] 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å |
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化合物 | ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP / ATP, エネルギー貯蔵分子*YM / アデノシン三リン酸
ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP / ADP, エネルギー貯蔵分子*YM / アデノシン二リン酸
ChemComp-NWM: (3R,4S,5R,6S,10R,11R,12R)-11-(acetyloxy)-1-(benzyloxy)-14-[formyl(methyl)amino]-5-hydroxy-4,6,10,12-tetramethyl-9-oxotetradecan-3-yl propanoate
ChemComp-1PO: N-{(1E,4R,5R,7E,9S,10S,11S)-4,10-dimethoxy-11-[(2S,4S,5S)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]-5,9-dimethyl-6-oxododeca-1,7-dien-1-yl}-N-methylformamide
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由来 | ![](img/tx_mammal.gif) ![](data/taxo/icon/Oryctolagus_cuniculus_S.png) oryctolagus cuniculus (ウサギ)
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キーワード | CONTRACTILE PROTEIN / actin filament (マイクロフィラメント) / cell motility (運動性) / gelsolin / citoplasm |
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