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-Structure paper
タイトル | Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. |
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ジャーナル・号・ページ | J Virol, Vol. 87, Issue 13, Page 7700-7707, Year 2013 |
掲載日 | 2013年5月1日 |
著者 | Victor A Kostyuchenko / Qian Zhang / Joanne L Tan / Thiam-Seng Ng / Shee-Mei Lok / |
PubMed 要旨 | Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, ...Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-Å resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation. |
リンク | J Virol / PubMed:23637416 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 4.5 - 6.0 Å |
構造データ | |
由来 |
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キーワード | VIRUS (ウイルス) / FLAVIVIRUS / PRM PROTEIN |