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-Structure paper
タイトル | A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease. |
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ジャーナル・号・ページ | Sci Rep, Vol. 5, Page 14440, Year 2015 |
掲載日 | 2015年9月23日 |
著者 | Brian L Gilmore / Carly E Winton / Andrew C Demmert / Justin R Tanner / Sam Bowman / Vasilea Karageorge / Kaya Patel / Zhi Sheng / Deborah F Kelly / |
PubMed 要旨 | We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable ...We present a new molecular toolkit to investigate protein assemblies natively formed in the context of human disease. The system employs tunable microchips that can be decorated with switchable adaptor molecules to select for target proteins of interest and analyze them using molecular microscopy. Implementing our new streamlined microchip approach, we could directly visualize BRCA1 gene regulatory complexes from patient-derived cancer cells for the first time. |
リンク | Sci Rep / PubMed:26395823 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 22.0 Å |
構造データ | EMDB-6340: |
由来 |
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