EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly.
ジャーナル・号・ページ	Nat Commun, Vol. 14, Issue 1, Page 2050, Year 2023
掲載日	2023年4月12日
著者	Zhennan Zhao / Youhua Huang / Congcong Liu / Dongjie Zhu / Shuaixin Gao / Sheng Liu / Ruchao Peng / Ya Zhang / Xiaohong Huang / Jianxun Qi / Catherine C L Wong / Xinzheng Zhang / Peiyi Wang / Qiwei Qin / George F Gao /
PubMed 要旨	Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and ...Singapore grouper iridovirus (SGIV), one of the nucleocytoviricota viruses (NCVs), is a highly pathogenic iridovirid. SGIV infection results in massive economic losses to the aquaculture industry and significantly threatens global biodiversity. In recent years, high morbidity and mortality in aquatic animals have been caused by iridovirid infections worldwide. Effective control and prevention strategies are urgently needed. Here, we present a near-atomic architecture of the SGIV capsid and identify eight types of capsid proteins. The viral inner membrane-integrated anchor protein colocalizes with the endoplasmic reticulum (ER), supporting the hypothesis that the biogenesis of the inner membrane is associated with the ER. Additionally, immunofluorescence assays indicate minor capsid proteins (mCPs) could form various building blocks with major capsid proteins (MCPs) before the formation of a viral factory (VF). These results expand our understanding of the capsid assembly of NCVs and provide more targets for vaccine and drug design to fight iridovirid infections.
リンク	Nat Commun / PubMed:37041173 / PubMed Central
手法	EM (単粒子)
解像度	3.4 - 9.0 Å
構造データ	EMDB-34227: Cryo-EM structure of Singapore Grouper Iridovirus capsid block 1 手法: EM (単粒子) / 解像度: 3.42 Å EMDB-34229: Cryo-EM structure of Singapore Grouper Iridovirus capsid block 4 手法: EM (単粒子) / 解像度: 3.51 Å EMDB-34230: Cryo-EM structure of Singapore Grouper Iridovirus capsid block 2 手法: EM (単粒子) / 解像度: 3.4 Å EMDB-34235: Cryo-EM structure of Singapore Grouper Iridovirus capsid block 3 手法: EM (単粒子) / 解像度: 3.42 Å EMDB-34236: Cryo-EM structure of Singapore Grouper Iridovirus capsid block 5 手法: EM (単粒子) / 解像度: 3.51 Å EMDB-34251: Singapore Grouper Iridovirus 手法: EM (単粒子) / 解像度: 9.0 Å 34815 8hif EMDB-34815, PDB-8hif: One asymmetric unit of Singapore grouper iridovirus capsid 手法: EM (単粒子) / 解像度: 3.5 Å
由来	singapore grouper iridovirus (ウイルス)
キーワード	VIRAL PROTEIN (ウイルスタンパク質) / Singapore grouper iridovirus / capsid proteins (カプシド)