EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.
ジャーナル・号・ページ	Nature, Vol. 618, Issue 7965, Page 590-597, Year 2023
掲載日	2023年5月31日
著者	Corey Momont / Ha V Dang / Fabrizia Zatta / Kevin Hauser / Caihong Wang / Julia di Iulio / Andrea Minola / Nadine Czudnochowski / Anna De Marco / Kaitlin Branch / David Donermeyer / Siddhant Vyas / Alex Chen / Elena Ferri / Barbara Guarino / Abigail E Powell / Roberto Spreafico / Samantha S Yim / Dale R Balce / Istvan Bartha / Marcel Meury / Tristan I Croll / David M Belnap / Michael A Schmid / William Timothy Schaiff / Jessica L Miller / Elisabetta Cameroni / Amalio Telenti / Herbert W Virgin / Laura E Rosen / Lisa A Purcell / Antonio Lanzavecchia / Gyorgy Snell / Davide Corti / Matteo Samuele Pizzuto /
PubMed 要旨	Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies ...Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies predominantly to the highly variable head region of haemagglutinin and their effectiveness is limited by viral drift and suboptimal immune responses. Here we describe a neuraminidase-targeting monoclonal antibody, FNI9, that potently inhibits the enzymatic activity of all group 1 and group 2 IAVs, as well as Victoria/2/87-like, Yamagata/16/88-like and ancestral IBVs. FNI9 broadly neutralizes seasonal IAVs and IBVs, including the immune-evading H3N2 strains bearing an N-glycan at position 245, and shows synergistic activity when combined with anti-haemagglutinin stem-directed antibodies. Structural analysis reveals that D107 in the FNI9 heavy chain complementarity-determinant region 3 mimics the interaction of the sialic acid carboxyl group with the three highly conserved arginine residues (R118, R292 and R371) of the neuraminidase catalytic site. FNI9 demonstrates potent prophylactic activity against lethal IAV and IBV infections in mice. The unprecedented breadth and potency of the FNI9 monoclonal antibody supports its development for the prevention of influenza illness by seasonal and pandemic viruses.
リンク	Nature / PubMed:37258672 / PubMed Central
手法	EM (単粒子)
解像度	2.2 - 3.1 Å
構造データ	29686 8g30 EMDB-29686, PDB-8g30: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules 手法: EM (単粒子) / 解像度: 3.1 Å 29704 8g3m EMDB-29704, PDB-8g3m: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI9 Fab molecules 手法: EM (単粒子) / 解像度: 3.0 Å 29705 8g3n EMDB-29705, PDB-8g3n: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules 手法: EM (単粒子) / 解像度: 2.9 Å 29706 8g3o EMDB-29706, PDB-8g3o: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules 手法: EM (単粒子) / 解像度: 3.1 Å 29707 8g3p EMDB-29707, PDB-8g3p: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules 手法: EM (単粒子) / 解像度: 2.5 Å 29708 8g3q EMDB-29708, PDB-8g3q: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI17 Fab molecules 手法: EM (単粒子) / 解像度: 2.3 Å 29709 8g3r EMDB-29709, PDB-8g3r: N2 neuraminidase of A/Tanzania/205/2010 H3N2 with S245N S247T mutations in complex with one FNI17 Fab molecule 手法: EM (単粒子) / 解像度: 2.3 Å 29710 8g3v EMDB-29710, PDB-8g3v: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules 手法: EM (単粒子) / 解像度: 2.2 Å 29711 8g3z EMDB-29711, PDB-8g3z: Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules 手法: EM (単粒子) / 解像度: 2.3 Å 29712 8g40 EMDB-29712, PDB-8g40: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules 手法: EM (単粒子) / 解像度: 2.8 Å
化合物	ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン / N-アセチルグルコサミン
由来	influenza a virus (A型インフルエンザウイルス) homo sapiens (ヒト) influenza b virus (B型インフルエンザウイルス)
キーワード	VIRAL PROTEIN/IMMUNE SYSTEM (ウイルス性) / viral glycoprotein / antibody (抗体) / Fab / influenza (インフルエンザ) / virus (ウイルス) / VIRAL PROTEIN-IMMUNE SYSTEM complex (ウイルス性)