EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Highly conserved protective epitopes on influenza B viruses.
ジャーナル・号・ページ	Science, Vol. 337, Issue 6100, Page 1343-1348, Year 2012
掲載日	2012年9月14日
著者	Cyrille Dreyfus / Nick S Laursen / Ted Kwaks / David Zuijdgeest / Reza Khayat / Damian C Ekiert / Jeong Hyun Lee / Zoltan Metlagel / Miriam V Bujny / Mandy Jongeneelen / Remko van der Vlugt / Mohammed Lamrani / Hans J W M Korse / Eric Geelen / Özcan Sahin / Martijn Sieuwerts / Just P J Brakenhoff / Ronald Vogels / Olive T W Li / Leo L M Poon / Malik Peiris / Wouter Koudstaal / Andrew B Ward / Ian A Wilson / Jaap Goudsmit / Robert H E Friesen /
PubMed 要旨	Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. ...Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
リンク	Science / PubMed:22878502 / PubMed Central
手法	EM (単粒子) / X線回折
解像度	1.71 - 19.0 Å
構造データ	EMDB-2143: Highly Conserved Protective Epitopes on Influenza B Viruses 手法: EM (単粒子) / 解像度: 15.0 Å EMDB-2144: Highly Conserved Protective Epitopes on Influenza B Viruses 手法: EM (単粒子) / 解像度: 17.0 Å EMDB-2145: Electron microscopy of Influenza hemagglutinin (Malaysia/2506/2004) in complex with neutralizing antibody (Fab CR8071 手法: EM (単粒子) / 解像度: 19.0 Å EMDB-2146: Electron microscopy of Influenza hemagglutinin (Malaysia/2506/2004) in complex with neutralizing antibody (Fab CR9114 手法: EM (単粒子) / 解像度: 18.0 Å EMDB-2147: Electron microscopy of Influenza hemagglutinin (South Carolina/1/1918 (H1N1)) in complex with neutralizing antibody (Fab CR9114) 手法: EM (単粒子) / 解像度: 18.0 Å EMDB-2148: Electron microscopy of Influenza hemagglutinin (Hong Kong/1/1968 (H3N2)) in complex with neutralizing antibody (Fab CR9114) 手法: EM (単粒子) / 解像度: 17.0 Å EMDB-2149: Electron microscopy of Influenza hemagglutinin (Wisconsin/1/1966 (H9N2)) in complex with neutralizing antibody (Fab CR9114) 手法: EM (単粒子) / 解像度: 14.8 Å EMDB-2150: Electron microscopy of Influenza hemagglutinin (Netherlands/219/2003 (H7N7)) in complex with neutralizing antibody (Fab CR9114) 手法: EM (単粒子) / 解像度: 17.5 Å PDB-4fqh: Crystal Structure of Fab CR9114 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4fqi: Crystal Structure of Fab CR9114 in Complex with a H5N1 influenza virus hemagglutinin 手法: X-RAY DIFFRACTION / 解像度: 1.71 Å PDB-4fqj: Influenza B/Florida/4/2006 hemagglutinin Fab CR8071 complex 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-4fqk: Influenza B/Brisbane/60/2008 hemagglutinin Fab CR8059 complex 手法: X-RAY DIFFRACTION / 解像度: 5.65 Å PDB-4fql: Influenza B HA Antibody (Fab) CR8033 手法: X-RAY DIFFRACTION / 解像度: 1.898 Å PDB-4fqm: Structure of B/Brisbane/60/2008 Influenza Hemagglutinin 手法: X-RAY DIFFRACTION / 解像度: 3.45 Å PDB-4fqv: Crystal structure of broadly neutralizing antibody CR9114 bound to H7 influenza hemagglutinin 手法: X-RAY DIFFRACTION / 解像度: 5.75 Å PDB-4fqy: Crystal structure of broadly neutralizing antibody CR9114 bound to H3 influenza hemagglutinin 手法: X-RAY DIFFRACTION / 解像度: 5.253 Å
化合物	ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル / エチレングリコール ChemComp-NO3: NITRATE ION / 硝酸塩 ChemComp-HOH: WATER / 水 ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン / N-アセチルグルコサミン ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン
由来	Influenza B virus (B/Florida/4/2006) (B型インフルエンザウイルス) homo sapiens (ヒト) Influenza B virus (B/Malaysia/2506/2004) (B型インフルエンザウイルス) Influenza A virus (A/South Carolina/1/1918(H1N1)) (A型インフルエンザウイルス) Influenza A virus (A/Hong Kong/1/1968(H3N2)) (A型インフルエンザウイルス) Influenza A virus (A/turkey/Wisconsin/1/1966(H9N2)) (A型インフルエンザウイルス) Influenza A virus (A/Netherlands/219/2003(H7N7)) (A型インフルエンザウイルス) influenza a virus (A型インフルエンザウイルス) influenza b virus (B型インフルエンザウイルス)
キーワード	IMMUNE SYSTEM (免疫系) / neutralizing antibodies (中和抗体) / antibody affinity / antigens (抗原) / epitope (エピトープ) / glycosylation (グリコシル化) / hemagglutinin glycoproteins / immunoglobulin Fab fragment / influenza virus (オルトミクソウイルス科) / influenza vaccines (インフルエンザワクチン) / membrane fusion / VIRAL PROTEIN/IMMUNE SYSTEM (ウイルス性) / epitopes (エピトープ) / immunoglobulin Fab fragments / H5N1 subtype / avian flu (鳥インフルエンザ) / envelope protein (エンベロープ (ウイルス)) / VIRAL PROTEIN-IMMUNE SYSTEM complex (ウイルス性) / monoclonal (単クローン性) / immunoglobulin (抗体) / antibody (抗体) / Fab fragment / viral (ウイルス性) / Influenza B virus (B型インフルエンザウイルス) / VIRAL PROTEIN (ウイルスタンパク質) / Hemagglutinin (ヘマグルチニン) / viral fusion protein / virus attachment and entry / immune recognition (免疫系)