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-Structure paper
タイトル | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. |
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ジャーナル・号・ページ | Structure, Vol. 28, Issue 7, Page 786-798.e6, Year 2020 |
掲載日 | 2020年7月7日 |
著者 | Yibin Xu / Nicholas S Kirk / Hariprasad Venugopal / Mai B Margetts / Tristan I Croll / Jarrod J Sandow / Andrew I Webb / Carlie A Delaine / Briony E Forbes / Michael C Lawrence / |
PubMed 要旨 | Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth ...Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like growth factor I. Here, we describe the cryoelectron microscopy structure of insulin-like growth factor II bound to a leucine-zipper-stabilized IGF-1R ectodomain, determined in two conformations to a maximum average resolution of 3.2 Å. The two conformations differ in the relative separation of their respective points of membrane entry, and comparison with the structure of insulin-like growth factor I bound to IGF-1R reveals long-suspected differences in the way in which the critical C domain of the respective growth factors interact with IGF-1R. |
リンク | Structure / PubMed:32459985 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.21 - 4.26 Å |
構造データ | EMDB-21415, PDB-6vwg: EMDB-21416, PDB-6vwh: EMDB-21417, PDB-6vwi: EMDB-21418, PDB-6vwj: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | SIGNALING PROTEIN / Type 1 insulin-like growth factor receptor / Insulin-like growth factor II / ectodomain receptor / tyrosine kinase |