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TitleCrystal structures of Tubercidin and Adenosine bound to the active site of the SARS-CoV-2 methyltransferase nsp10-16
Journal, issue, pagesTo Be Published
Publish dateDec 15, 2022 (structure data deposition date)
AuthorsKremling, V. / Sprenger, J. / Oberthuer, D. / Falke, S. / Yefanov, O. / Galchenkova, M. / Middendorf, P. / Fernandez Garcia, Y. / Ehrt, C. / Kiene, A. ...Kremling, V. / Sprenger, J. / Oberthuer, D. / Falke, S. / Yefanov, O. / Galchenkova, M. / Middendorf, P. / Fernandez Garcia, Y. / Ehrt, C. / Kiene, A. / Klopprogge, B. / Chapman, H.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.67 - 2.21 Å
Structure data

PDB-8bzv:
SARS-CoV-2 nsp10-16 methyltransferase in complex with adenosine
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8c5m:
SARS-CoV-2 nsp10-16 methyltransferase in complex with MTA
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8osx:
SARS-CoV-2 nsp10-16 methyltransferase in complex with ATP
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-8ot0:
SARS-CoV-2 nsp10-16 methyltransferase in complex with MTA and glycine
Method: X-RAY DIFFRACTION / Resolution: 2.21 Å

PDB-8oto:
SARS-CoV-2 nsp10-16 methyltransferase in complex with AMP
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-8otr:
SARS-CoV-2 nsp10-16 methyltransferase in complex with SAM analog BDH 33959089
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

PDB-8ov1:
SARS-CoV-2 nsp10-16 methyltransferase in complex with ADP
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-8ov2:
SARS-CoV-2 nsp10-16 methyltransferase in complex with Sangivamycin
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-8ov3:
SARS-CoV-2 nsp10-16 methyltransferase in complex with 5-Iodotubercidin
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

Chemicals

ChemComp-ADN:
ADENOSINE / Adenosine

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM / MES (buffer)

ChemComp-CL:
Unknown entry / Chloride

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-MTA:
5'-DEOXY-5'-METHYLTHIOADENOSINE / 5′-Methylthioadenosine

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

ChemComp-SAM:
S-ADENOSYLMETHIONINE / S-Adenosyl methionine

ChemComp-GLY:
GLYCINE / Glycine

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM / Adenosine monophosphate

ChemComp-W08:
(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-N-(1-methylpiperidin-4-yl)-3,4-bis(oxidanyl)oxolane-2-carboxamide

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM / Adenosine diphosphate

ChemComp-SGV:
SANGIVAMYCIN / inhibitor*YM / Sangivamycin

ChemComp-5ID:
(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / Methyltransferase / Complex / Inhibitor / protein complex / SARS-CoV-2

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