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-Structure paper
Title | Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content |
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Journal, issue, pages | To be Published |
Publish date | Jan 25, 2013 (structure data deposition date) |
Authors | Waring, M.J. / Bennett, S.N.L. / Boyd, S. / Campbell, L. / Davies, R.D.M. / Gerhardt, S. / Hargreaves, D. / G Martin, N. / Robb, G.R. / Wilkinson, G. |
External links | Search PubMed |
Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | PDB-4ixc: |
Chemicals | ChemComp-NA: ChemComp-GLC: ChemComp-1JD: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / Allosteric Regulation / Binding Sites / Catalytic Domain / Diabetes Mellitus / Type 2 / Enzyme Activators / Glucokinase / Hexokinase / Humans / Models / Molecular / Mutation / Protein Conformation / TRANSFERASE-TRANSFERASE INHIBITOR complex |