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TitleStructural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange.
Journal, issue, pagesElife, Vol. 12, Year 2023
Publish dateJun 23, 2023
AuthorsDavid N Tippett / Colum Breen / Stephen J Butler / Marta Sawicka / Raimund Dutzler /
PubMed AbstractMembers of the SLC26 family constitute a conserved class of anion transport proteins, which encompasses uncoupled transporters with channel-like properties, coupled exchangers and motor proteins. ...Members of the SLC26 family constitute a conserved class of anion transport proteins, which encompasses uncoupled transporters with channel-like properties, coupled exchangers and motor proteins. Among the 10 functional paralogs in humans, several participate in the secretion of bicarbonate in exchange with chloride and thus play an important role in maintaining pH homeostasis. Previously, we have elucidated the structure of murine SLC26A9 and defined its function as an uncoupled chloride transporter (Walter et al., 2019). Here we have determined the structure of the closely related human transporter SLC26A6 and characterized it as a coupled exchanger of chloride with bicarbonate and presumably also oxalate. The structure defines an inward-facing conformation of the protein that generally resembles known structures of SLC26A9. The altered anion selectivity between both paralogs is a consequence of a remodeled ion binding site located in the center of a mobile unit of the membrane-inserted domain, which also accounts for differences in the coupling mechanism.
External linksElife / PubMed:37351578 / PubMed Central
MethodsEM (single particle)
Resolution3.28 Å
Structure data

17085

8opq

EMDB-17085, PDB-8opq:
Structure of Human Solute Carrier 26 family member A6 (SLC26A6) anion transporter in an inward-facing state
Method: EM (single particle) / Resolution: 3.28 Å

Chemicals

ChemComp-CL:
Unknown entry / Chloride

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Homodimer / Transporter / Exchanger / Bicarbonate / Chloride / Oxalate MEMBRANE PROTEIN

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