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Title | Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 10433-10459, Year 2020 |
Publish date | Aug 20, 2020 (structure data deposition date) |
Authors | Du, X. / Moore, J. / Blank, B.R. / Eksterowicz, J. / Sutimantanapi, D. / Yuen, N. / Metzger, T. / Chan, B. / Huang, T. / Chen, X. ...Du, X. / Moore, J. / Blank, B.R. / Eksterowicz, J. / Sutimantanapi, D. / Yuen, N. / Metzger, T. / Chan, B. / Huang, T. / Chen, X. / Chen, Y. / Duong, F. / Kong, W. / Chang, J.H. / Sun, J. / Zavorotinskaya, T. / Ye, Q. / Junttila, M.R. / Ndubaku, C. / Friedman, L.S. / Fantin, V.R. / Sun, D. |
External links | J. Med. Chem. / PubMed:32865411 |
Methods | X-ray diffraction |
Resolution | 2.46 - 2.7 Å |
Structure data | PDB-7jv8: PDB-7jv9: |
Chemicals | ChemComp-ZN: ChemComp-CA: ChemComp-VPD: ChemComp-HOH: ChemComp-NAG: ChemComp-VPG: ChemComp-PO4: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / 5'-NUCLEOTIDASE / HYDROLASE / PHOSPHATASE / PROTEROS / PROTEROS BIOSTRUCTURES GMBH / HYDROLASE-HYDROLASE INHIBITOR complex |