+Search query
-Structure paper
Title | Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 62, Page 7769-7787, Year 2019 |
Publish date | Mar 28, 2019 (structure data deposition date) |
Authors | Munck Af Rosenschold, M. / Johannesson, P. / Nikitidis, A. / Tyrchan, C. / Chang, H.F. / Ronn, R. / Chapman, D. / Ullah, V. / Nikitidis, G. / Glader, P. ...Munck Af Rosenschold, M. / Johannesson, P. / Nikitidis, A. / Tyrchan, C. / Chang, H.F. / Ronn, R. / Chapman, D. / Ullah, V. / Nikitidis, G. / Glader, P. / Kack, H. / Bonn, B. / Wagberg, F. / Bjorkstrand, E. / Andersson, U. / Swedin, L. / Rohman, M. / Andreasson, T. / Bergstrom, E.L. / Jiang, F. / Zhou, X.H. / Lundqvist, A.J. / Malmberg, A. / Ek, M. / Gordon, E. / Pettersen, A. / Ripa, L. / Davis, A.M. |
External links | J. Med. Chem. / PubMed:31415176 |
Methods | X-ray diffraction |
Resolution | 2.35 Å |
Structure data | PDB-6r7d: |
Chemicals | ChemComp-JUQ: ChemComp-NI: ChemComp-PLM: ChemComp-LMT: ChemComp-HOH: |
Source |
|
Keywords | MEMBRANE PROTEIN / Inhibitor / arachidonic acid cascade / cysteinyl leukotrienes |