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Title | Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 141, Page 5051-5061, Year 2019 |
Publish date | Mar 13, 2019 (structure data deposition date) |
Authors | Matsushita, T. / Sati, G.C. / Kondasinghe, N. / Pirrone, M.G. / Kato, T. / Waduge, P. / Kumar, H.S. / Sanchon, A.C. / Dobosz-Bartoszek, M. / Shcherbakov, D. ...Matsushita, T. / Sati, G.C. / Kondasinghe, N. / Pirrone, M.G. / Kato, T. / Waduge, P. / Kumar, H.S. / Sanchon, A.C. / Dobosz-Bartoszek, M. / Shcherbakov, D. / Juhas, M. / Hobbie, S.N. / Schrepfer, T. / Chow, C.S. / Polikanov, Y.S. / Schacht, J. / Vasella, A. / Bottger, E.C. / Crich, D. |
External links | J. Am. Chem. Soc. / PubMed:30793894 |
Methods | X-ray diffraction |
Resolution | 2.75 Å |
Structure data | PDB-6o97: |
Chemicals | ChemComp-MG: ChemComp-LUJ: ChemComp-K: ChemComp-ZN: ChemComp-SF4: ChemComp-HOH: |
Source |
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Keywords | RIBOSOME/ANTIBIOTIC / Propylamycin / aminoglycosides / antibiotic / 70S ribosome / inhibition of translation / decoding center / RIBOSOME-ANTIBIOTIC complex |