+Search query
-Structure paper
Title | 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 62, Page 1793-1802, Year 2019 |
Publish date | Sep 4, 2018 (structure data deposition date) |
![]() | Sarver, P. / Acker, M. / Bagdanoff, J.T. / Chen, Z. / Chen, Y.N. / Chan, H. / Firestone, B. / Fodor, M. / Fortanet, J. / Hao, H. ...Sarver, P. / Acker, M. / Bagdanoff, J.T. / Chen, Z. / Chen, Y.N. / Chan, H. / Firestone, B. / Fodor, M. / Fortanet, J. / Hao, H. / Hentemann, M. / Kato, M. / Koenig, R. / LaBonte, L.R. / Liu, G. / Liu, S. / Liu, C. / McNeill, E. / Mohseni, M. / Sendzik, M. / Stams, T. / Spence, S. / Tamez, V. / Tichkule, R. / Towler, C. / Wang, H. / Wang, P. / Williams, S.L. / Yu, B. / LaMarche, M.J. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.96 - 2.34 Å |
Structure data | ![]() PDB-6md7: ![]() PDB-6mdb: |
Chemicals | ![]() ChemComp-JE1: ![]() ChemComp-PO4: ![]() ChemComp-HOH: ![]() ChemComp-JE4: |
Source |
|
![]() | HYDROLASE/HYDROLASE INHIBITOR / ![]() ![]() ![]() ![]() ![]() |