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TitleStructure of the mammalian TRPM7, a magnesium channel required during embryonic development.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 115, Issue 35, Page E8201-E8210, Year 2018
Publish dateAug 28, 2018
AuthorsJingjing Duan / Zongli Li / Jian Li / Raymond E Hulse / Ana Santa-Cruz / William C Valinsky / Sunday A Abiria / Grigory Krapivinsky / Jin Zhang / David E Clapham /
PubMed AbstractThe transient receptor potential ion channel subfamily M, member 7 (TRPM7), is a ubiquitously expressed protein that is required for mouse embryonic development. TRPM7 contains both an ion channel ...The transient receptor potential ion channel subfamily M, member 7 (TRPM7), is a ubiquitously expressed protein that is required for mouse embryonic development. TRPM7 contains both an ion channel and an α-kinase. The channel domain comprises a nonselective cation channel with notable permeability to Mg and Zn Here, we report the closed state structures of the mouse TRPM7 channel domain in three different ionic conditions to overall resolutions of 3.3, 3.7, and 4.1 Å. The structures reveal key residues for an ion binding site in the selectivity filter, with proposed partially hydrated Mg ions occupying the center of the conduction pore. In high [Mg], a prominent external disulfide bond is found in the pore helix, which is essential for ion channel function. Our results provide a structural framework for understanding the TRPM1/3/6/7 subfamily and extend the knowledge base upon which to study the diversity and evolution of TRP channels.
External linksProc Natl Acad Sci U S A / PubMed:30108148 / PubMed Central
MethodsEM (single particle)
Resolution3.28 - 4.1 Å
Structure data

6975

5zx5

EMDB-6975, PDB-5zx5:
3.3 angstrom structure of mouse TRPM7 with EDTA
Method: EM (single particle) / Resolution: 3.28 Å

7297

6bwd

EMDB-7297, PDB-6bwd:
3.7 angstrom cryoEM structure of truncated mouse TRPM7
Method: EM (single particle) / Resolution: 3.7 Å

7298

6bwf

EMDB-7298, PDB-6bwf:
4.1 angstrom Mg2+-unbound structure of mouse TRPM7
Method: EM (single particle) / Resolution: 4.1 Å

Chemicals

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER / Water

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / CryoEM / Truncated mouse TRPM7 / MEMBRANE PROTEIN

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