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TitleFour-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release.
Journal, issue, pagesAngew Chem Int Ed Engl, Vol. 57, Issue 11, Page 2909-2913, Year 2018
Publish dateMar 5, 2018
AuthorsByungjun Ahn / Seong-Gyu Lee / Hye Ryeon Yoon / Jeong Min Lee / Hyeok Jin Oh / Ho Min Kim / Yongwon Jung /
PubMed AbstractHuman ferritins are emerging platforms for non-toxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug ...Human ferritins are emerging platforms for non-toxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high-level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nanocages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of Fe -conjugated drugs as well as pH-responsive rapid drug release at endoplasmic pH. Multiple cancer-related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.
External linksAngew Chem Int Ed Engl / PubMed:29359486
MethodsEM (single particle)
Resolution3.0 Å
Structure data

6714

5xb1

EMDB-6714, PDB-5xb1:
human ferritin mutant - E-helix deletion
Method: EM (single particle) / Resolution: 3.0 Å

6830

5yi5

EMDB-6830, PDB-5yi5:
human ferritin mutant - E-helix deletion
Method: EM (single particle) / Resolution: 3.0 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / ferritin / cage / drug delivery

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