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Title | AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. |
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Journal, issue, pages | Cancer Discov, Vol. 7, Page 478-493, Year 2017 |
Publish date | Feb 19, 2016 (structure data deposition date) |
Authors | Yen, K. / Travins, J. / Wang, F. / David, M.D. / Artin, E. / Straley, K. / Padyana, A. / Gross, S. / DeLaBarre, B. / Tobin, E. ...Yen, K. / Travins, J. / Wang, F. / David, M.D. / Artin, E. / Straley, K. / Padyana, A. / Gross, S. / DeLaBarre, B. / Tobin, E. / Chen, Y. / Nagaraja, R. / Choe, S. / Jin, L. / Konteatis, Z. / Cianchetta, G. / Saunders, J.O. / Salituro, F.G. / Quivoron, C. / Opolon, P. / Bawa, O. / Saada, V. / Paci, A. / Broutin, S. / Bernard, O.A. / de Botton, S. / Marteyn, B.S. / Pilichowska, M. / Xu, Y. / Fang, C. / Jiang, F. / Wei, W. / Jin, S. / Silverman, L. / Liu, W. / Yang, H. / Dang, L. / Dorsch, M. / Penard-Lacronique, V. / Biller, S.A. / Su, S.M. |
External links | Cancer Discov / PubMed:28193778 |
Methods | X-ray diffraction |
Resolution | 1.54 - 1.55 Å |
Structure data | PDB-5i95: PDB-5i96: |
Chemicals | ChemComp-NDP: ChemComp-CA: ChemComp-GOL: ChemComp-ACT: ChemComp-AKG: ChemComp-HOH: ChemComp-NA: ChemComp-69Q: |
Source |
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Keywords | OXIDOREDUCTASE / IDH / ICD-M / IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase / aKG / alphaKG / oxo-glutarate. / OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / IDH2 / enasidenib / AG-221 / IDH2 AG-221 / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |