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-Structure paper
Title | Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 27, Page 551-556, Year 2017 |
Publish date | Sep 28, 2016 (structure data deposition date) |
Authors | Heinrich, T. / Buchstaller, H.P. / Cezanne, B. / Rohdich, F. / Bomke, J. / Friese-Hamim, M. / Krier, M. / Knochel, T. / Musil, D. / Leuthner, B. / Zenke, F. |
External links | Bioorg. Med. Chem. Lett. / PubMed:27998678 |
Methods | X-ray diffraction |
Resolution | 1.69 - 1.9 Å |
Structure data | PDB-5lyw: PDB-5lyx: |
Chemicals | ChemComp-7BH: ChemComp-MN: ChemComp-HOH: ChemComp-7BF: |
Source |
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Keywords | HYDROLASE / PEPTIDASE / METAL ION BINDING / PROTEOLYSIS / HYDROLASE- HYDROLASE INHIBITOR COMPLEX |