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TitleMolecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus.
Journal, issue, pagesSci Transl Med, Vol. 8, Issue 369, Page 369ra179, Year 2016
Publish dateDec 14, 2016
AuthorsQihui Wang / Huabing Yang / Xiaoqing Liu / Lianpan Dai / Tong Ma / Jianxun Qi / Gary Wong / Ruchao Peng / Sheng Liu / Junfu Li / Shihua Li / Jian Song / Jianying Liu / Jianhua He / Hui Yuan / Ying Xiong / Yong Liao / Jianhua Li / Jianping Yang / Zhou Tong / Bryan D Griffin / Yuhai Bi / Mifang Liang / Xiaoning Xu / Chuan Qin / Gong Cheng / Xinzheng Zhang / Peiyi Wang / Xiangguo Qiu / Gary Kobinger / Yi Shi / Jinghua Yan / George F Gao /
PubMed AbstractThe 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and ...The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV. These two antibodies provided postexposure protection to mice in vivo. Structural studies revealed that Z23 and Z3L1 bound to tertiary epitopes in envelope protein domain I, II, or III, indicating potential targets for ZIKV-specific therapy. Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.
External linksSci Transl Med / PubMed:27974667
MethodsEM (single particle) / X-ray diffraction
Resolution2.755 - 9.4 Å
Structure data

9542

5gzr

EMDB-9542: Zika virus complexed with a neutralizing antibody Z23-Fab
PDB-5gzr: Zika virus E protein complexed with a neutralizing antibody Z23-Fab
Method: EM (single particle) / Resolution: 9.4 Å

PDB-5gzn:
Structure of neutralizing antibody bound to Zika envelope protein
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-5gzo:
Structure of neutralizing antibody bound to Zika envelope protein
Method: X-RAY DIFFRACTION / Resolution: 2.755 Å

Source
  • zika virus
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Zika virus / human neutralizing antibody / envelope protein / molecular determinants / VIRAL PROTEIN-IMMUNE SYSTEM complex / Human neutralizing antibodies / VIRUS / Neutralizing antibody / Single Particle Reconstruction

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