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TitleA Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.
Journal, issue, pagesImmunity, Vol. 45, Issue 1, Page 31-45, Year 2016
Publish dateJul 19, 2016
AuthorsDevin Sok / Matthias Pauthner / Bryan Briney / Jeong Hyun Lee / Karen L Saye-Francisco / Jessica Hsueh / Alejandra Ramos / Khoa M Le / Meaghan Jones / Joseph G Jardine / Raiza Bastidas / Anita Sarkar / Chi-Hui Liang / Sachin S Shivatare / Chung-Yi Wu / William R Schief / Chi-Huey Wong / Ian A Wilson / Andrew B Ward / Jiang Zhu / Pascal Poignard / Dennis R Burton /
PubMed AbstractThe dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs). This region is ...The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs). This region is relatively conserved, implying functional importance, the origins of which are not well understood. Here we describe the isolation of new bnAbs targeting this region. Examination of these and previously described antibodies to Env revealed that four different bnAb families targeted the (324)GDIR(327) peptide stretch at the base of the gp120 V3 loop and its nearby glycans. We found that this peptide stretch constitutes part of the CCR5 co-receptor binding site, with the high-mannose patch glycans serving to camouflage it from most antibodies. GDIR-glycan bnAbs, in contrast, bound both (324)GDIR(327) peptide residues and high-mannose patch glycans, which enabled broad reactivity against diverse HIV isolates. Thus, as for the CD4 binding site, bnAb effectiveness relies on circumventing the defenses of a critical functional region on Env.
External linksImmunity / PubMed:27438765 / PubMed Central
MethodsEM (single particle)
Resolution21.0 Å
Structure data

EMDB-8181:
Broadly neutralizing antibody PGDM14 in complex with BG505 SOSIP.664 Env trimer
Method: EM (single particle) / Resolution: 21.0 Å

EMDB-8182:
Broadly neutralizing antibody PGDM21 in complex with BG505 SOSIP.664 Env trimer
Method: EM (single particle) / Resolution: 21.0 Å

Source
  • Human immunodeficiency virus 1
  • Homo sapiens (human)

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