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TitleIsolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.
Journal, issue, pagesScience, Vol. 351, Issue 6277, Page 1078-1083, Year 2016
Publish dateMar 4, 2016
AuthorsZachary A Bornholdt / Hannah L Turner / Charles D Murin / Wen Li / Devin Sok / Colby A Souders / Ashley E Piper / Arthur Goff / Joshua D Shamblin / Suzanne E Wollen / Thomas R Sprague / Marnie L Fusco / Kathleen B J Pommert / Lisa A Cavacini / Heidi L Smith / Mark Klempner / Keith A Reimann / Eric Krauland / Tillman U Gerngross / Karl D Wittrup / Erica Ollmann Saphire / Dennis R Burton / Pamela J Glass / Andrew B Ward / Laura M Walker /
PubMed AbstractAntibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain ...Antibodies targeting the Ebola virus surface glycoprotein (EBOV GP) are implicated in protection against lethal disease, but the characteristics of the human antibody response to EBOV GP remain poorly understood. We isolated and characterized 349 GP-specific monoclonal antibodies (mAbs) from the peripheral B cells of a convalescent donor who survived the 2014 EBOV Zaire outbreak. Remarkably, 77% of the mAbs neutralize live EBOV, and several mAbs exhibit unprecedented potency. Structures of selected mAbs in complex with GP reveal a site of vulnerability located in the GP stalk region proximal to the viral membrane. Neutralizing antibodies targeting this site show potent therapeutic efficacy against lethal EBOV challenge in mice. The results provide a framework for the design of new EBOV vaccine candidates and immunotherapies.
External linksScience / PubMed:26912366 / PubMed Central
MethodsEM (single particle)
Resolution18.0 - 24.0 Å
Structure data

EMDB-6586:
Negative stain EM of Ebola virus GP bound to human survivor antibodies
Method: EM (single particle) / Resolution: 18.0 Å

EMDB-6587:
Negative stain EM of Ebola virus GP bound to human survivor antibodies
Method: EM (single particle) / Resolution: 18.0 Å

EMDB-6588:
Negative stain EM of Ebola virus GP bound to human survivor antibodies
Method: EM (single particle) / Resolution: 24.0 Å

EMDB-6589:
Negative stain EM of Ebola virus GP bound to human survivor antibodies
Method: EM (single particle) / Resolution: 24.0 Å

Source
  • Ebola virus sp.
  • Homo sapiens (human)

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