タイトル | Molecular mechanism of respiratory syncytial virus fusion inhibitors. |
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ジャーナル・号・ページ | Nat. Chem. Biol., Vol. 12, Page 87-93, Year 2016 |
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掲載日 | 2015年10月15日 (構造データの登録日) |
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著者 | Battles, M.B. / Langedijk, J.P. / Furmanova-Hollenstein, P. / Chaiwatpongsakorn, S. / Costello, H.M. / Kwanten, L. / Vranckx, L. / Vink, P. / Jaensch, S. / Jonckers, T.H. ...Battles, M.B. / Langedijk, J.P. / Furmanova-Hollenstein, P. / Chaiwatpongsakorn, S. / Costello, H.M. / Kwanten, L. / Vranckx, L. / Vink, P. / Jaensch, S. / Jonckers, T.H. / Koul, A. / Arnoult, E. / Peeples, M.E. / Roymans, D. / McLellan, J.S. |
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リンク | Nat. Chem. Biol. / PubMed:26641933 |
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手法 | X線回折 |
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解像度 | 2.3 - 3.05 Å |
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構造データ | PDB-5ea3: Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-5ea4: Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5ea5: Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein 手法: X-RAY DIFFRACTION / 解像度: 3.05 Å PDB-5ea6: Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-5ea7: Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein 手法: X-RAY DIFFRACTION / 解像度: 2.851 Å PDB-5ea8: Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å |
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化合物 | ChemComp-5NK: 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol
ChemComp-5NM: 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one
ChemComp-TM3: 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol
ChemComp-5NP: (9~{b}~{R})-9~{b}-(4-chlorophenyl)-1-pyridin-3-ylcarbonyl-2,3-dihydroimidazo[5,6]pyrrolo[1,2-~{a}]pyridin-5-one
ChemComp-5NO: 1-cyclopropyl-3-[[1-(4-oxidanylbutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one / BMS-433771
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由来 | ![](img/tx_virus.gif) human respiratory syncytial virus a (strain a2) (RSウイルス)
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キーワード | CELL INVASION/INHIBITOR / Class I viral fusion protein / fusion / respiratory syncytial virus (RSウイルス) / prefusion / viral protein (ウイルスタンパク質) / fusion inhibitor (侵入阻害剤) / CELL INVASION-INHIBITOR complex |
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