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TitlePROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Journal, issue, pagesScience, Vol. 349, Page 187-191, Year 2015
Publish dateJan 25, 2015 (structure data deposition date)
AuthorsRen, R. / Zhou, X. / He, Y. / Ke, M. / Wu, J. / Liu, X. / Yan, C. / Wu, Y. / Gong, X. / Lei, X. ...Ren, R. / Zhou, X. / He, Y. / Ke, M. / Wu, J. / Liu, X. / Yan, C. / Wu, Y. / Gong, X. / Lei, X. / Yan, S.F. / Radhakrishnan, A. / Yan, N.
External linksScience / PubMed:26160948
MethodsX-ray diffraction
Resolution1.898 - 2.1 Å
Structure data

PDB-4xu4:
Crystal structure of a mycobacterial Insig homolog MvINS from Mycobacterium vanbaalenii at 1.9A resolution
Method: X-RAY DIFFRACTION / Resolution: 1.901 Å

PDB-4xu5:
Crystal structure of MvINS bound to a bromine-derived 14C Diacylglycerol (DAG) at 2.1A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4xu6:
Crystal structure of cross-linked MvINS R77C trimer at 1.9A resolution
Method: X-RAY DIFFRACTION / Resolution: 1.898 Å

Chemicals

ChemComp-BNG:
nonyl beta-D-glucopyranoside / detergent*YM

ChemComp-DDQ:
DECYLAMINE-N,N-DIMETHYL-N-OXIDE

ChemComp-HOH:
WATER / Water

ChemComp-LBR:
(2S)-1-[(13-bromotridecanoyl)oxy]-3-hydroxypropan-2-yl tetradecanoate

ChemComp-D10:
DECANE / Decane

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM / Octyl glucoside

ChemComp-TDA:
N-TRIDECANOIC ACID / Tridecylic acid

Source
  • mycobacterium vanbaalenii pyr-1 (bacteria)
KeywordsUNKNOWN FUNCTION

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