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TitleStructural comparison of four different antibodies interacting with human papillomavirus 16 and mechanisms of neutralization.
Journal, issue, pagesVirology, Vol. 483, Page 253-263, Year 2015
Publish dateMay 19, 2015
AuthorsJian Guan / Stephanie M Bywaters / Sarah A Brendle / Hyunwook Lee / Robert E Ashley / Alexander M Makhov / James F Conway / Neil D Christensen / Susan Hafenstein /
PubMed AbstractCryo-electron microscopy (cryo-EM) was used to solve the structures of human papillomavirus type 16 (HPV16) complexed with fragments of antibody (Fab) from three different neutralizing monoclonals ...Cryo-electron microscopy (cryo-EM) was used to solve the structures of human papillomavirus type 16 (HPV16) complexed with fragments of antibody (Fab) from three different neutralizing monoclonals (mAbs): H16.1A, H16.14J, and H263.A2. The structure-function analysis revealed predominantly monovalent binding of each Fab with capsid interactions that involved multiple loops from symmetry related copies of the major capsid protein. The residues identified in each Fab-virus interface map to a conformational groove on the surface of the capsomer. In addition to the known involvement of the FG and HI loops, the DE loop was also found to constitute the core of each epitope. Surprisingly, the epitope mapping also identified minor contributions by EF and BC loops. Complementary immunological assays included mAb and Fab neutralization. The specific binding characteristics of mAbs correlated with different neutralizing behaviors in pre- and post-attachment neutralization assays.
External linksVirology / PubMed:25996608 / PubMed Central
MethodsEM (single particle)
Resolution13.0 - 14.0 Å
Structure data

5990

3j8z

EMDB-5990: Electron cryo-microscopy of quasi-human papillomavirus 16 complexed with Fab H16.1A
PDB-3j8z: Cryo-EM reconstruction of quasi-HPV16 complex with H16.1A Fab
Method: EM (single particle) / Resolution: 14.0 Å

6121

3j8v

EMDB-6121: Cryo-EM reconstruction of quasi-HPV16 complexed with H16.14J Fab
PDB-3j8v: Cryo-EM reconstruction of quasi-HPV16 complex with H16.14J Fab
Method: EM (single particle) / Resolution: 13.9 Å

6184

3j8w

EMDB-6184: Cryo-EM reconstruction of quasi-HPV16 complexed with H263.A2 Fab
PDB-3j8w: Cryo-EM reconstruction of quasi-HPV16 complex with H263.A2 Fab
Method: EM (single particle) / Resolution: 13.0 Å

Source
  • unidentified (others)
  • mus musculus (house mouse)
  • human papillomavirus type 16
KeywordsVIRUS/IMMUNE SYSTEM / L1 pentamer / quasi-HPV16 / L1 capsomer / Rosie online / VIRUS-IMMUNE SYSTEM complex

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