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Structure paper

TitleMultifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Journal, issue, pagesJ. Virol., Vol. 89, Page 6848-6859, Year 2015
Publish dateNov 17, 2014 (structure data deposition date)
AuthorsFerrer-Orta, C. / de la Higuera, I. / Caridi, F. / Sanchez-Aparicio, M.T. / Moreno, E. / Perales, C. / Singh, K. / Sarafianos, S.G. / Sobrino, F. / Domingo, E. / Verdaguer, N.
External linksJ. Virol. / PubMed:25903341
MethodsX-ray diffraction
Resolution1.8 - 2.94 Å
Structure data

PDB-4wyl:
Mutant K18E of 3D polymerase from Foot-and-Moth Disease Virus
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-4wyw:
Mutant K20E of 3D polymerase from Foot-and-Mouth Disease Virus
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4wzm:
Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed with RNA
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

PDB-4wzq:
Mutant K20E of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus complexed with RNA
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-4x2b:
K20A RNA dependent RNA polymerase mutant from Foot-and-Mouth disease Virus complexed with an RNA
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

Chemicals

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-ACT:
ACETATE ION / Acetate

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-3PO:
TRIPHOSPHATE / Polyphosphate

ChemComp-MG:
Unknown entry

Source
  • foot-and-mouth disease virus
  • synthetic construct (others)
KeywordsTRANSFERASE / closed-right hand RNA dependent RNA polymerase / closed-right hand RNA dependent RNA polymerase Picornavirus / Picornavirus / Nuclear Localization Signal / RNA dependent RNA polymerase / closed right-hand / Nuclear Signal Localization / Foot-and-Mouth disease / Virus / 3D polymerase

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