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Structure paper

TitleCommon polymorphisms in human langerin change specificity for glycan ligands.
Journal, issue, pagesJ. Biol. Chem., Vol. 288, Page 36762-36771, Year 2013
Publish dateOct 6, 2013 (structure data deposition date)
AuthorsFeinberg, H. / Rowntree, T.J. / Tan, S.L. / Drickamer, K. / Weis, W.I. / Taylor, M.E.
External linksJ. Biol. Chem. / PubMed:24217250
MethodsX-ray diffraction
Resolution1.75 - 2 Å
Structure data

PDB-4n32:
Structure of langerin CRD with alpha-Me-GlcNAc.
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4n33:
Structure of langerin CRD complexed with GlcNAc-beta1-3Gal-beta1-4Glc-beta-CH2CH2N3
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4n34:
Structure of langerin CRD I313 with alpha-MeGlcNAc
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-4n35:
Structure of langerin CRD I313 complexed with GlcNAc-beta1-3Gal-beta1-4Glc-beta-CH2CH2N3
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4n36:
Structure of langerin CRD I313 D288 complexed with Me-GlcNAc
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-4n37:
Structure of langerin CRD I313 D288 complexed with Me-Man
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-4n38:
Structure of langerin CRD I313 D288 complexed with GlcNAc-beta1-3Gal-beta1-4GlcNAc-beta-CH2CH2N3
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

Chemicals

ChemComp-2F8:
methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside / Methyl group

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-MG:
Unknown entry

ChemComp-MMA:
methyl alpha-D-mannopyranoside / Methylglucoside

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN / CRD carbohydrate complex / carbohydrate-recognition domain / C-type lectin on Langerhans cells / Carbohydrate/Sugar Binding / receptor on Langerhans cells

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