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TitleThe structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.
Journal, issue, pagesStructure, Vol. 21, Issue 8, Page 1396-1405, Year 2013
Publish dateAug 6, 2013
AuthorsUlrike E Maurer / Tzviya Zeev-Ben-Mordehai / Arun Prasad Pandurangan / Tina M Cairns / Brian P Hannah / J Charles Whitbeck / Roselyn J Eisenberg / Gary H Cohen / Maya Topf / Juha T Huiskonen / Kay Grünewald /
PubMed AbstractGlycoprotein B (gB) is a key component of the complex herpesvirus fusion machinery. We studied membrane interaction of two gB ectodomain forms and present an electron cryotomography structure of the ...Glycoprotein B (gB) is a key component of the complex herpesvirus fusion machinery. We studied membrane interaction of two gB ectodomain forms and present an electron cryotomography structure of the gB-bilayer complex. The two forms differed in presence or absence of the membrane proximal region (MPR) but showed an overall similar trimeric shape. The presence of the MPR impeded interaction with liposomes. In contrast, the MPR-lacking form interacted efficiently with liposomes. Lateral interaction resulted in coat formation on the membranes. The structure revealed that interaction of gB with membranes was mediated by the fusion loops and limited to the outer membrane leaflet. The observed intrinsic propensity of gB to cluster on membranes indicates an additional role of gB in driving the fusion process forward beyond the transient fusion pore opening and subsequently leading to fusion pore expansion.
External linksStructure / PubMed:23850455 / PubMed Central
MethodsEM (subtomogram averaging) / EM (tomography)
Resolution27.0 - 30.0 Å
Structure data

EMDB-2379:
Structure of herpesvirus fusion glycoprotein B-bilayer complex revealing the protein-membrane and lateral protein-protein interaction
Method: EM (subtomogram averaging) / Resolution: 30.0 Å

2380

4bom

EMDB-2380, PDB-4bom:
Structure of herpesvirus fusion glycoprotein B-bilayer complex revealing the protein-membrane and lateral protein-protein interaction
Method: EM (subtomogram averaging) / Resolution: 27.0 Å

Source
  • human herpesvirus 1 (Herpes simplex virus type 1)
KeywordsVIRAL PROTEIN / MEMBRANE PROXIMAL REGION / PROTEIN COAT / PSEUDO-ATOMIC VIRUS-HOST INTERACTION

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