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Title | Potent Proteasome Inhibitors Derived from the Unnatural cis-Cyclopropane Isomer of Belactosin A: Synthesis, Biological Activity, and Mode of Action. |
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Journal, issue, pages | J. Med. Chem., Vol. 56, Page 3689-3700, Year 2013 |
Publish date | Feb 12, 2013 (structure data deposition date) |
Authors | Kawamura, S. / Unno, Y. / List, A. / Mizuno, A. / Tanaka, M. / Sasaki, T. / Arisawa, M. / Asai, A. / Groll, M. / Shuto, S. |
External links | J. Med. Chem. / PubMed:23547757 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-4j70: |
Chemicals | ChemComp-1KR: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Proteasome / drug discovery / irreversible inhibition / beta-lactone / Ntn hydrolase / HYDROLASE-HYDROLASE INHIBITOR complex |