Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Structural investigations of a Podoviridae streptococcus phage C1, implications for the mechanism of viral entry.
Journal, issue, pages	Proc Natl Acad Sci U S A, Vol. 109, Issue 35, Page 14001-14006, Year 2012
Publish date	Aug 28, 2012
Authors	Anastasia A Aksyuk / Valorie D Bowman / Bärbel Kaufmann / Christopher Fields / Thomas Klose / Heather A Holdaway / Vincent A Fischetti / Michael G Rossmann /
PubMed Abstract	The Podoviridae phage C1 was one of the earliest isolated bacteriophages and the first virus documented to be active against streptococci. The icosahedral and asymmetric reconstructions of the virus ...The Podoviridae phage C1 was one of the earliest isolated bacteriophages and the first virus documented to be active against streptococci. The icosahedral and asymmetric reconstructions of the virus were calculated using cryo-electron microscopy. The capsid protein has an HK97 fold arranged into a T = 4 icosahedral lattice. The C1 tail is terminated with a ϕ29-like knob, surrounded by a skirt of twelve long appendages with novel morphology. Several C1 structural proteins have been identified, including a candidate for an appendage. The crystal structure of the knob has an N-terminal domain with a fold observed previously in tube forming proteins of Siphoviridae and Myoviridae phages. The structure of C1 suggests the mechanisms by which the virus digests the cell wall and ejects its genome. Although there is little sequence similarity to other phages, conservation of the structural proteins demonstrates a common origin of the head and tail, but more recent evolution of the appendages.
External links	Proc Natl Acad Sci U S A / PubMed:22891295 / PubMed Central
Methods	EM (single particle) / X-ray diffraction
Resolution	3.007 - 24.0 Å
Structure data	EMDB-5445: Icosahedral reconstruction of the Streptococcus phage C1 capsid Method: EM (single particle) / Resolution: 8.3 Å EMDB-5446: Asymmetric reconstruction of the Streptococcus phage C1 Method: EM (single particle) / Resolution: 24.0 Å PDB-4eo2: Structure of the bacteriophage C1 tail knob protein, gp12 Method: X-RAY DIFFRACTION / Resolution: 3.007 Å PDB-4ep0: Structure of the bacteriophage C1 tail knob protein, gp12 Method: X-RAY DIFFRACTION / Resolution: 4.0 Å
Source	streptococcus phage c1 (virus)
Keywords	STRUCTURAL PROTEIN / VIRAL PROTEIN