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Title | Exploiting differences in caspase-2 and -3 S(2) subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 19, Page 5833-5851, Year 2011 |
Publish date | Apr 15, 2011 (structure data deposition date) |
Authors | Maillard, M.C. / Brookfield, F.A. / Courtney, S.M. / Eustache, F.M. / Gemkow, M.J. / Handel, R.K. / Johnson, L.C. / Johnson, P.D. / Kerry, M.A. / Krieger, F. ...Maillard, M.C. / Brookfield, F.A. / Courtney, S.M. / Eustache, F.M. / Gemkow, M.J. / Handel, R.K. / Johnson, L.C. / Johnson, P.D. / Kerry, M.A. / Krieger, F. / Meniconi, M. / Munoz-Sanjuan, I. / Palfrey, J.J. / Park, H. / Schaertl, S. / Taylor, M.G. / Weddell, D. / Dominguez, C. |
External links | Bioorg. Med. Chem. / PubMed:21903398 |
Methods | X-ray diffraction |
Resolution | 2.55 Å |
Structure data | PDB-3rjm: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / caspase-2 / p12 / p19 / caspase / HYDROLASE-HYDROLASE INHIBITOR complex |