EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
ジャーナル・号・ページ	Proc. Natl. Acad. Sci. USA, Vol. 107, Page 20057-20062, Year 2010
掲載日	2010年9月23日 (構造データの登録日)
著者	Hare, S. / Vos, A.M. / Clayton, R.F. / Thuring, J.W. / Cummings, M.D. / Cherepanov, P.
リンク	Proc. Natl. Acad. Sci. USA / PubMed:21030679
手法	X線回折
解像度	2.02 - 2.74 Å
構造データ	PDB-3oya: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and raltegravir at 2.65 resolution 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-3oyb: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI MK2048 手法: X-RAY DIFFRACTION / 解像度: 2.54 Å PDB-3oyc: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI PICA 手法: X-RAY DIFFRACTION / 解像度: 2.66 Å PDB-3oyd: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI GS9160 手法: X-RAY DIFFRACTION / 解像度: 2.54 Å PDB-3oye: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI Compound2 手法: X-RAY DIFFRACTION / 解像度: 2.74 Å PDB-3oyf: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI L-870,810 手法: X-RAY DIFFRACTION / 解像度: 2.51 Å PDB-3oyg: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI Compound1 (CompoundG) 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-3oyh: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI MK0536 手法: X-RAY DIFFRACTION / 解像度: 2.74 Å PDB-3oyi: Crystal structure of the PFV S217Q mutant intasome in complex with manganese 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-3oyj: Crystal structure of the PFV S217Q mutant intasome in complex with magnesium and the INSTI MK2048 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å PDB-3oyk: Crystal structure of the PFV S217H mutant intasome bound to manganese 手法: X-RAY DIFFRACTION / 解像度: 2.72 Å PDB-3oyl: Crystal structure of the PFV S217H mutant intasome bound to magnesium and the INSTI MK2048 手法: X-RAY DIFFRACTION / 解像度: 2.54 Å PDB-3oym: Crystal structure of the PFV N224H mutant intasome bound to manganese 手法: X-RAY DIFFRACTION / 解像度: 2.02 Å PDB-3oyn: Crystal structure of the PFV N224H mutant intasome bound to magnesium and the INSTI MK2048 手法: X-RAY DIFFRACTION / 解像度: 2.68 Å
化合物	ChemComp-ZN: Unknown entry ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン ChemComp-NH4: AMMONIUM ION / アンモニウム / アンモニウム ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-RLT: N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di / ラルテグラビル / 薬剤, 抗レトロウイルス剤YM / ラルテグラビル ChemComp-HOH: WATER / 水 ChemComp-ZZX: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide / 阻害剤YM / MK-2048 ChemComp-ZZW: 9-(4-fluorobenzyl)-N-hydroxy-9H-beta-carboline-3-carboxamide ChemComp-ZZV: N-[7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-5-yl]-N-methylmethanesulfonamide ChemComp-ZYY: N-[(6S)-2-(4-fluorobenzyl)-10-hydroxy-6-methyl-8-(1-methylethyl)-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazin-4-yl]-N-methylmethanesulfonamide ChemComp-ZYP: 5-(1,1-dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide / L-870810 ChemComp-ZYO: (6S)-2-(3-chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-6-methyl-4-(5-methyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione ChemComp-ZYN: 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-2-(1-methylethyl)-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide / N,N-ジメチル-2-イソプロピル-3,5-ジオキソ-4-ヒドロキシ-6-(3-クロロ-4-フルオロベンジル)-2,3(以下略) ChemComp-MN: Unknown entry ChemComp-HEZ: HEXANE-1,6-DIOL / 1,6-ヘキサンジオ-ル / 1,6-Hexanediol
由来	human spumaretrovirus (ウイルス)
キーワード	RECOMBINATION (遺伝的組換え) / VIRAL PROTEIN/DNA (ウイルス性) / PROTEIN-DNA COMPLEX (デオキシリボ核酸) / TETRAMER (四量体) / DNA INTEGRATION / ENDONUCLEASE (エンドヌクレアーゼ) / METAL-BINDING / MULTIFUNCTIONAL ENZYME / NUCLEASE (ヌクレアーゼ) / NUCLEOTIDYLTRANSFERASE / NUCLEUS (細胞核) / TRANSFERASE (転移酵素) / VIRAL NUCLEOPROTEIN / VIRION (ウイルス) / DNA-BINDING / ZINC BINDING (亜鉛) / HHCC MOTIF / VIRAL PROTEIN (ウイルスタンパク質) / INHIBITOR (酵素阻害剤) / DNA-BINDING PROTEIN-DNA complex / VIRAL PROTEIN-DNA complex (ウイルス性)