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Title | Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521). |
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Journal, issue, pages | J. Med. Chem., Vol. 53, Page 3814-3830, Year 2010 |
Publish date | Mar 15, 2010 (structure data deposition date) |
![]() | Watterson, S.H. / Xiao, Z. / Dodd, D.S. / Tortolani, D.R. / Vaccaro, W. / Potin, D. / Launay, M. / Stetsko, D.K. / Skala, S. / Davis, P.M. ...Watterson, S.H. / Xiao, Z. / Dodd, D.S. / Tortolani, D.R. / Vaccaro, W. / Potin, D. / Launay, M. / Stetsko, D.K. / Skala, S. / Davis, P.M. / Lee, D. / Yang, X. / McIntyre, K.W. / Balimane, P. / Patel, K. / Yang, Z. / Marathe, P. / Kadiyala, P. / Tebben, A.J. / Sheriff, S. / Chang, C.Y. / Ziemba, T. / Zhang, H. / Chen, B.C. / DelMonte, A.J. / Aranibar, N. / McKinnon, M. / Barrish, J.C. / Suchard, S.J. / Murali Dhar, T.G. |
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Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | ![]() PDB-3m6f: |
Chemicals | ![]() ChemComp-BJZ: ![]() ChemComp-NO3: ![]() ChemComp-HOH: |
Source |
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