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-Structure paper
Title | Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 3915-3926, Year 2009 |
Publish date | Oct 31, 2008 (structure data deposition date) |
Authors | Getlik, M. / Grutter, C. / Simard, J.R. / Kluter, S. / Rabiller, M. / Rode, H.B. / Robubi, A. / Rauh, D. |
External links | J. Med. Chem. / PubMed:19462975 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.6 Å |
Structure data | PDB-3f3v: PDB-3f3w: PDB-3g5d: |
Chemicals | ChemComp-1BU: ChemComp-HOH: ChemComp-1N1: ChemComp-GOL: |
Source |
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Keywords | TRANSFERASE / Allosteric / Type II / DFG-out / ATP-binding / Kinase / Lipoprotein / Myristate / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase / Drug resistance mutation / Alternative splicing / Dasatinib |