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Structure paper

TitleFrom the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 104, Page 5782-5787, Year 2007
Publish dateFeb 12, 2007 (structure data deposition date)
AuthorsWang, H. / Liu, Y. / Hou, J. / Zheng, M. / Robinson, H. / Ke, H.
External linksProc. Natl. Acad. Sci. Usa / PubMed:17389385
MethodsX-ray diffraction
Resolution1.45 - 1.9 Å
Structure data

PDB-2oun:
crystal structure of PDE10A2 in complex with AMP
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-2oup:
crystal structure of PDE10A
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-2ouq:
crystal structure of PDE10A2 in complex with GMP
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2our:
crystal structure of PDE10A2 mutant D674A in complex with cAMP
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-2ous:
crystal structure of PDE10A2 mutant D674A
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-2ouu:
crystal structure of PDE10A2 mutant D674A in complex with cGMP
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-2ouv:
crystal structure of pde10a2 mutant of D564N
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-2ouy:
crystal structure of pde10a2 mutant D564A in complex with cAMP.
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM / Adenosine monophosphate

ChemComp-HOH:
WATER / Water

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE / Guanosine monophosphate

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE / Cyclic adenosine monophosphate

ChemComp-35G:
GUANOSINE-3',5'-MONOPHOSPHATE / Guanosine monophosphate

Source
  • homo sapiens (human)
KeywordsHYDROLASE / pde / product binding / pde10 / gmp complex / cAMP / substrate specificity / cGMP

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