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-Structure paper
Title | The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. |
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Journal, issue, pages | Structure, Vol. 13, Issue 7, Page 1019-1033, Year 2005 |
Publish date | Dec 9, 2005 |
![]() | Chuan Xiao / Carol M Bator-Kelly / Elizabeth Rieder / Paul R Chipman / Alister Craig / Richard J Kuhn / Eckard Wimmer / Michael G Rossmann / ![]() |
PubMed Abstract | CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human ...CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1. |
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Methods | EM (single particle) / X-ray diffraction |
Resolution | 3.2 - 8.0 Å |
Structure data | EMDB-1114: The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. ![]() PDB-1z7s: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-MYR: ![]() ChemComp-G: ![]() ChemComp-HOH: ![]() ChemComp-NAG: |
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