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-Structure paper
Title | Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics |
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Journal, issue, pages | Nature, Vol. 432, Page 59-67, Year 2004 |
Publish date | Jul 7, 2004 (structure data deposition date) |
Authors | Xiao, T. / Takagi, J. / Coller, B.S. / Wang, J.-H. / Springer, T.A. |
External links | Nature / PubMed:15378069 |
Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | PDB-1tye: |
Chemicals | ChemComp-CA: ChemComp-NAG: ChemComp-CAC: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | CELL ADHESION / crystal structure; platelet integrin alphaIIBbeta3; fibrinogen binding; allostery; therapeutic antagonism |