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Structure paper

TitleStructure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.
Journal, issue, pagesCell, Vol. 166, Issue 6, Page 1411-1422.e16, Year 2016
Publish dateSep 8, 2016
AuthorsPhilip J Robinson / Michael J Trnka / David A Bushnell / Ralph E Davis / Pierre-Jean Mattei / Alma L Burlingame / Roger D Kornberg /
PubMed AbstractA complete, 52-protein, 2.5 million dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking and mass ...A complete, 52-protein, 2.5 million dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed by cryo-electron microscopy and by chemical cross-linking and mass spectrometry. The resulting complete Med-PIC structure reveals two components of functional significance, absent from previous structures, a protein kinase complex and the Mediator-activator interaction region. It thereby shows how the kinase and its target, the C-terminal domain of the polymerase, control Med-PIC interaction and transcription.
External linksCell / PubMed:27610567 / PubMed Central
MethodsEM (single particle)
Resolution15.3 - 21.9 Å
Structure data

8305

5sva

EMDB-8305: Mediator-RNA Polymerase II Pre-Initiation Complex Delta Mediator Tail (Focused Refinement)
PDB-5sva: Mediator-RNA Polymerase II Pre-Initiation Complex
Method: EM (single particle) / Resolution: 15.3 Å

EMDB-8307:
Mediator-RNA Polymerase II Pre-Initiation Complex Delta TFIIE-IIH (Focused refinement)
Method: EM (single particle) / Resolution: 16.8 Å

EMDB-8308:
Mediator-RNA Polymerase II Pre-Initiation Complex
Method: EM (single particle) / Resolution: 21.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • yeast (fungus)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSCRIPTION / TRANSFERASE/DNA / Transcriptional Initiation / Mediator / Pre-Initiation Complex / Carboxy-terminal domain (CTD) / TRANSFERASE-DNA complex

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