2BC4
 
 | | Crystal structure of HLA-DM | | Descriptor: | CHLORIDE ION, HLA class II histocompatibility antigen, DM alpha chain, ... | | Authors: | Nicholson, M.J, Moradi, B, Seth, N.P, Xing, X, Cuny, G.D, Stein, R.L, Wucherpfennig, K.W. | | Deposit date: | 2005-10-18 | | Release date: | 2006-05-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Small molecules that enhance the catalytic efficiency of HLA-DM.
J.Immunol., 176, 2006
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4FQX
 | | Crystal structure of HLA-DM bound to HLA-DR1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DM alpha chain, ... | | Authors: | Sethi, D.K, Pos, W, Wucherpfennig, K.W. | | Deposit date: | 2012-06-25 | | Release date: | 2013-01-09 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.599 Å) | | Cite: | Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
Cell(Cambridge,Mass.), 151, 2012
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3PL6
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1JK8
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1YMM
 | | TCR/HLA-DR2b/MBP-peptide complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ... | | Authors: | Hahn, M, Nicholson, M.J, Pyrdol, J, Wucherpfennig, K.W. | | Deposit date: | 2005-01-21 | | Release date: | 2005-05-03 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
NAT.IMMUNOL., 6, 2005
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4GBX
 | | Crystal structure of an immune complex at pH 6.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DM alpha chain, ... | | Authors: | Sethi, D.K, Pos, W, Wucherpfennig, K.W. | | Deposit date: | 2012-07-28 | | Release date: | 2013-01-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection.
Cell(Cambridge,Mass.), 151, 2012
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4GRL
 | | Crystal structure of a autoimmune TCR-MHC complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II antigen, ... | | Authors: | Sethi, D.K, Wucherpfennig, K.W. | | Deposit date: | 2012-08-25 | | Release date: | 2013-11-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
Nat Commun, 4, 2013
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2HAC
 | | Structure of Zeta-Zeta Transmembrane Dimer | | Descriptor: | T-cell surface glycoprotein CD3 zeta chain | | Authors: | Chou, J.J, Wucherpfennig, K.W, Schnell, J.R, Call, M.E. | | Deposit date: | 2006-06-12 | | Release date: | 2006-10-31 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.
Cell(Cambridge,Mass.), 127, 2006
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2K4F
 | | Mouse CD3epsilon Cytoplasmic Tail | | Descriptor: | T-cell surface glycoprotein CD3 epsilon chain | | Authors: | Xu, C, Call, M.E, Schwieters, C.D, Schnell, J.R, Gagnon, E.E, Wucherpfennig, K.W, Chou, J.J. | | Deposit date: | 2008-06-07 | | Release date: | 2008-12-02 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3varepsilon Cytoplasmic Tyrosine-Based Motif.
Cell(Cambridge,Mass.), 135, 2008
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2L34
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2L35
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4MAY
 | | Crystal structure of an immune complex | | Descriptor: | HY.1B11 TCR alpha chain, MHC class II HLA-DQ-alpha chain, MHC class II antigen, ... | | Authors: | Sethi, D.K, Wucherpfennig, K.W. | | Deposit date: | 2013-08-18 | | Release date: | 2013-10-23 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
Nat Commun, 4, 2013
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1BX2
 | | CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (HLA-DR2) | | Authors: | Smith, K.J, Pyrdol, J, Gauthier, L, Wiley, D.C, Wucherpfennig, K. | | Deposit date: | 1998-10-12 | | Release date: | 1998-10-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.
J.Exp.Med., 188, 1998
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2IJ0
 | | Structural basis of T cell specificity and activation by the bacterial superantigen toxic shock syndrome toxin-1 | | Descriptor: | Toxic shock syndrome toxin-1, penultimate affinity-matured variant of hVbeta 2.1, D10 | | Authors: | Moza, B, Varma, A.K, Buonpane, R.A, Zhu, P, Herfst, C.A, Nicholson, M.J, Wilbuer, A.K, Nulifer, S, Wucherpfenning, K.W, McCormick, J.K, Kranz, D.M, Sundberg, E.J. | | Deposit date: | 2006-09-28 | | Release date: | 2007-02-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1.
Embo J., 26, 2007
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5W1M
 | | MACV GP1 CR1-07 Fab complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR1-07 Fab heavy chain, ... | | Authors: | Raymond, D.D, Clark, L.E, Abraham, J. | | Deposit date: | 2017-06-03 | | Release date: | 2018-05-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.91 Å) | | Cite: | Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
Nat Commun, 9, 2018
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5W1G
 | | CR1-07 unliganded Fab | | Descriptor: | CR1-07 Fab heavy chain, CR1-07 Fab light chain | | Authors: | Raymond, D.D, Clark, L.E, Abraham, J. | | Deposit date: | 2017-06-03 | | Release date: | 2018-05-30 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
Nat Commun, 9, 2018
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5W1K
 | | JUNV GP1 CR1-10 Fab CR1-28 Fab complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR1-10 Fab heavy chain, ... | | Authors: | Raymond, D.D, Clark, L.E, Abraham, J. | | Deposit date: | 2017-06-03 | | Release date: | 2018-05-30 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.99 Å) | | Cite: | Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
Nat Commun, 9, 2018
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4P2Q
 | | Crystal structure of the 5cc7 TCR in complex with 5c2/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c2 peptide, 5cc7 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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4P2R
 | | Crystal structure of the 5cc7 TCR in complex with 5c1/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c1 peptide, 5cc7 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.295 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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4P2O
 | | Crystal structure of the 2B4 TCR in complex with 2A/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2A peptide, 2B4 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.603 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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