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7PAG
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BU of 7pag by Molmil
The pore conformation of lymphocyte perforin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Perforin-1
Authors:Ivanova, M.E, Lukoyanova, N, Malhotra, S, Topf, M, Trapani, J.A, Voskoboinik, I, Saibil, H.R.
Deposit date:2021-07-29
Release date:2022-02-16
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The pore conformation of lymphocyte perforin.
Sci Adv, 8, 2022
2QP2
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BU of 2qp2 by Molmil
Structure of a MACPF/perforin-like protein
Descriptor: CALCIUM ION, Unknown protein
Authors:Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
5UG6
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BU of 5ug6 by Molmil
Perforin C2 Domain - T431D
Descriptor: IODIDE ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
5UG7
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BU of 5ug7 by Molmil
Calcium bound Perforin C2 Domain - T431D
Descriptor: CALCIUM ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
4V3N
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BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3A
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BU of 4v3a by Molmil
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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BU of 4v3m by Molmil
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OEJ
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BU of 4oej by Molmil
Structure of membrane binding protein pleurotolysin B from Pleurotus ostreatus
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Dunstone, M.A, Caradoc-Davies, T.T, Whisstock, J.C, Law, R.H.P.
Deposit date:2014-01-13
Release date:2015-02-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OV8
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BU of 4ov8 by Molmil
Crystal Structure of the TMH1-lock mutant of the mature form of pleurotolysin B
Descriptor: CHLORIDE ION, GLYCEROL, Pleurotolysin B, ...
Authors:Kondos, S.C, Law, R.H.P, Whisstock, J.C, Dunstone, M.A.
Deposit date:2014-02-20
Release date:2015-02-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Plos Biol., 13, 2015
4OEB
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BU of 4oeb by Molmil
Structure of membrane binding protein pleurotolysin A from Pleurotus ostreatus
Descriptor: Pleurotolysin A, SULFATE ION
Authors:Dunstone, M.A, Caradoc-Davies, T.T, Whisstock, J.C, Law, R.H.P.
Deposit date:2014-01-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
3NSJ
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BU of 3nsj by Molmil
The X-ray crystal structure of lymphocyte perforin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Law, R.H, Whisstock, J.C, Caradoc-Davies, T.T.
Deposit date:2010-07-01
Release date:2010-11-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The structural basis for membrane binding and pore formation by lymphocyte perforin.
Nature, 468, 2010
4Y1S
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BU of 4y1s by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.611 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
4Y1T
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BU of 4y1t by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.666 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
3W56
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BU of 3w56 by Molmil
Structure of a C2 domain
Descriptor: C2 domain protein
Authors:Traore, D.A.K, Whisstock, J.C.
Deposit date:2013-01-24
Release date:2013-10-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Defining the interaction of perforin with calcium and the phospholipid membrane.
Biochem.J., 456, 2013
3W57
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BU of 3w57 by Molmil
Structure of a C2 domain
Descriptor: C2 domain protein, CALCIUM ION
Authors:Traore, D.A.K, Whisstock, J.C.
Deposit date:2013-01-24
Release date:2013-10-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.662 Å)
Cite:Defining the interaction of perforin with calcium and the phospholipid membrane.
Biochem.J., 456, 2013
6U2J
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BU of 6u2j by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2W
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BU of 6u2w by Molmil
EM structure of MPEG-1(L425K) pre-pore complex bound to liposome
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U23
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BU of 6u23 by Molmil
EM structure of MPEG-1(w.t.) soluble pre-pore
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-19
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2L
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BU of 6u2l by Molmil
EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2K
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BU of 6u2k by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019

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