Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1G5B
DownloadVisualize
BU of 1g5b by Molmil
BACTERIOPHAGE LAMBDA SER/THR PROTEIN PHOSPHATASE
Descriptor: MANGANESE (II) ION, MERCURY (II) ION, SERINE/THREONINE PROTEIN PHOSPHATASE, ...
Authors:Voegtli, W.C, White, D.J, Reiter, N.J, Rusnak, F, Rosenzweig, A.C.
Deposit date:2000-10-31
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of the bacteriophage lambda Ser/Thr protein phosphatase with sulfate ion bound in two coordination modes.
Biochemistry, 39, 2000
1JK0
DownloadVisualize
BU of 1jk0 by Molmil
Ribonucleotide reductase Y2Y4 heterodimer
Descriptor: ZINC ION, ribonucleoside-diphosphate reductase small chain 1, ribonucleoside-diphosphate reductase small chain 2
Authors:Voegtli, W.C, Perlstein, D.L, Ge, J, Stubbe, J, Rosenzweig, A.C.
Deposit date:2001-07-10
Release date:2001-09-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.
Proc.Natl.Acad.Sci.USA, 98, 2001
1PIY
DownloadVisualize
BU of 1piy by Molmil
RIBONUCLEOTIDE REDUCTASE R2 SOAKED WITH FERROUS ION AT NEUTRAL PH
Descriptor: FE (III) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Saleh, L, Baldwin, J, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
1PIM
DownloadVisualize
BU of 1pim by Molmil
DITHIONITE REDUCED E. COLI RIBONUCLEOTIDE REDUCTASE R2 SUBUNIT, D84E MUTANT
Descriptor: FE (III) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Khidekel, N, Baldwin, J, Ley, B.A, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Ribonucleotide Reductase R2 Mutant that Accumulates a u-1,2-Peroxodiiron(III) Intermediate during Oxygen Activation
J.Am.Chem.Soc., 122, 2000
1PGU
DownloadVisualize
BU of 1pgu by Molmil
YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM
Descriptor: Actin interacting protein 1, ZINC ION
Authors:Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
Deposit date:2003-05-28
Release date:2003-07-15
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1PJ0
DownloadVisualize
BU of 1pj0 by Molmil
RIBONUCLEOTIDE REDUCTASE R2-D84E/W48F MUTANT SOAKED WITH FERROUS IONS AT NEUTRAL PH
Descriptor: FE (III) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Saleh, L, Baldwin, J, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
1PI6
DownloadVisualize
BU of 1pi6 by Molmil
YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM
Descriptor: Actin interacting protein 1, ZINC ION
Authors:Voegtli, W.C, Madrona, A.Y, Wilson, D.K.
Deposit date:2003-05-29
Release date:2003-07-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.
J.Biol.Chem., 278, 2003
1PJ1
DownloadVisualize
BU of 1pj1 by Molmil
RIBONUCLEOTIDE REDUCTASE R2-D84E/W48F SOAKED WITH FERROUS IONS AT PH 5
Descriptor: FE (III) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Saleh, L, Baldwin, J, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
1PIZ
DownloadVisualize
BU of 1piz by Molmil
RIBONUCLEOTIDE REDUCTASE R2 D84E MUTANT SOAKED WITH FERROUS IONS AT NEUTRAL PH
Descriptor: FE (III) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Saleh, L, Baldwin, J, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
1PIU
DownloadVisualize
BU of 1piu by Molmil
OXIDIZED RIBONUCLEOTIDE REDUCTASE R2-D84E MUTANT CONTAINING OXO-BRIDGED DIFERRIC CLUSTER
Descriptor: FE (III) ION, MERCURY (II) ION, OXYGEN ATOM, ...
Authors:Voegtli, W.C, Khidekel, N, Baldwin, J, Ley, B.A, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-05-30
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Ribonucleotide Reductase R2 Mutant that Accumulates a u-1,2-Peroxodiiron(III) Intermediate during Oxygen Activation
J.Am.Chem.Soc., 122, 2000
1PM2
DownloadVisualize
BU of 1pm2 by Molmil
CRYSTAL STRUCTURE OF MANGANESE SUBSTITUTED R2-D84E (D84E MUTANT OF THE R2 SUBUNIT OF E. COLI RIBONUCLEOTIDE REDUCTASE)
Descriptor: MANGANESE (II) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Baldwin, J, Saleh, L, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-06-09
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
1R65
DownloadVisualize
BU of 1r65 by Molmil
Crystal structure of ferrous soaked Ribonucleotide Reductase R2 subunit (wildtype) at pH 5 from E. coli
Descriptor: FE (II) ION, MERCURY (II) ION, Ribonucleoside-diphosphate reductase 1 beta chain
Authors:Voegtli, W.C, Sommerhalter, M, Saleh, L, Baldwin, J, Bollinger Jr, J.M, Rosenzweig, A.C.
Deposit date:2003-10-14
Release date:2004-01-13
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Variable coordination geometries at the diiron(II) active site of ribonucleotide reductase R2.
J.Am.Chem.Soc., 125, 2003
3TV6
DownloadVisualize
BU of 3tv6 by Molmil
Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor
Descriptor: 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Sturgis, H.L, Wu, W.-I.
Deposit date:2011-09-19
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.
ACS Med Chem Lett, 2, 2011
3TV4
DownloadVisualize
BU of 3tv4 by Molmil
Human B-Raf Kinase Domain in Complex with an Bromopyridine Benzamide Inhibitor
Descriptor: N-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Selby, L.T, Wu, W.-I.
Deposit date:2011-09-19
Release date:2011-10-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.
ACS Med Chem Lett, 2, 2011
4G9R
DownloadVisualize
BU of 4g9r by Molmil
B-Raf V600E Kinase Domain Bound to a Type II Dihydroquinazoline Inhibitor
Descriptor: 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Sturgis, H.L.
Deposit date:2012-07-24
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4G9C
DownloadVisualize
BU of 4g9c by Molmil
Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor
Descriptor: 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Sturgis, H.L.
Deposit date:2012-07-23
Release date:2012-11-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4MBJ
DownloadVisualize
BU of 4mbj by Molmil
Human B-Raf Kinase Domain in Complex with an Imidazopyridine-based Inhibitor
Descriptor: 2,6-difluoro-N-(1H-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C.
Deposit date:2013-08-19
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase.
Bioorg.Med.Chem.Lett., 23, 2013
4MLE
DownloadVisualize
BU of 4mle by Molmil
Human Glucokinase in Complex with Novel Amino Thiazole Activator
Descriptor: 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
4MLH
DownloadVisualize
BU of 4mlh by Molmil
Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator
Descriptor: 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine, Glucokinase, alpha-D-glucopyranose
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
4EHG
DownloadVisualize
BU of 4ehg by Molmil
B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor
Descriptor: N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C.
Deposit date:2012-04-02
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties.
J.Med.Chem., 55, 2012
4EHE
DownloadVisualize
BU of 4ehe by Molmil
B-Raf Kinase Domain in Complex with an Aminothienopyrimidine-based Inhibitor
Descriptor: 4-amino-N-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C.
Deposit date:2012-04-02
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties.
J.Med.Chem., 55, 2012
4E4X
DownloadVisualize
BU of 4e4x by Molmil
Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor
Descriptor: N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Sturgis, H.L.
Deposit date:2012-03-13
Release date:2012-05-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 22, 2012
3O96
DownloadVisualize
BU of 3o96 by Molmil
Crystal Structure of Human AKT1 with an Allosteric Inhibitor
Descriptor: 1-(1-(4-(7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one, RAC-alpha serine/threonine-protein kinase
Authors:Voegtli, W.C, Wu, W.-I, Lord-Ondash, H.A, Dizon, F.P, Vigers, G.P.A, Brandhuber, B.J.
Deposit date:2010-08-03
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.
Plos One, 5, 2010
3PRF
DownloadVisualize
BU of 3prf by Molmil
Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor
Descriptor: 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-29
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3PRI
DownloadVisualize
BU of 3pri by Molmil
Crystal Structure of Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor
Descriptor: 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1H-indazol-3-yl)propan-1-ol, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-29
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011

 

12>

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon