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6VJ8
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BU of 6vj8 by Molmil
Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor
Descriptor: Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2020-01-15
Release date:2020-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
6VJ9
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BU of 6vj9 by Molmil
Crystal structure of GlpG in complex with peptide boronate inhibitor
Descriptor: ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2020-01-15
Release date:2020-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
6XRP
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BU of 6xrp by Molmil
Crystal structure of GlpG in complex with peptide ketoamide inhibitor, Ac-RVWHA-ketoamide-phenylbutyl
Descriptor: N-(4-phenylbutyl)formamide, Rhomboid protease GlpG, peptide ketoamide inhibitor
Authors:Urban, S, Cho, S.
Deposit date:2020-07-13
Release date:2020-09-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
6XRO
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BU of 6xro by Molmil
Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2
Descriptor: CHLORIDE ION, Rhomboid protease GlpG, SODIUM ION, ...
Authors:Urban, S, Cho, S.
Deposit date:2020-07-13
Release date:2020-09-16
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Cell Chem Biol, 27, 2020
6PJU
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BU of 6pju by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJR
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BU of 6pjr by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: CHLORIDE ION, Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJA
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BU of 6pja by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ5
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BU of 6pj5 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-27
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ9
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BU of 6pj9 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ7
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BU of 6pj7 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJQ
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BU of 6pjq by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-11-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ8
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BU of 6pj8 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJP
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BU of 6pjp by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-28
Release date:2019-10-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
6PJ4
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BU of 6pj4 by Molmil
Time-resolved structural snapshot of proteolysis by GlpG inside the membrane
Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG
Authors:Urban, S, Cho, S.
Deposit date:2019-06-27
Release date:2019-10-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release.
Nat.Struct.Mol.Biol., 26, 2019
5F5J
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BU of 5f5j by Molmil
E.coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle
Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde
Authors:Urban, S, Cho, S, Dickey, S.
Deposit date:2015-12-04
Release date:2016-02-10
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Mol.Cell, 61, 2016
5F5B
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BU of 5f5b by Molmil
Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO
Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde
Authors:Urban, S, Cho, S, Dickey, S.W.
Deposit date:2015-12-04
Release date:2016-02-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Mol.Cell, 61, 2016
5F5D
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BU of 5f5d by Molmil
Crystal structures and Inhibition kinetics reveal a two-state catalytic mechanism with drug design implications for rhomboid proteolysis
Descriptor: Rhomboid protease GlpG
Authors:Urban, S, Cho, S, Dickey, S.W.
Deposit date:2015-12-04
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Mol.Cell, 61, 2016
5F5G
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BU of 5f5g by Molmil
Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle
Descriptor: ACE-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG
Authors:Urban, S, Cho, S, Dickey, S.W.
Deposit date:2015-12-04
Release date:2016-04-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Mol.Cell, 61, 2016
5F5K
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BU of 5f5k by Molmil
E.Coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle
Descriptor: Peptidic derivative of Gurken: ACE-ARG-LYS-VAL-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG
Authors:Urban, S, Cho, S, Dickey, S.W.
Deposit date:2015-12-04
Release date:2016-02-10
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Mol.Cell, 61, 2016
8RQF
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BU of 8rqf by Molmil
Cryo-EM structure of human NTCP-Bulevirtide complex
Descriptor: Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ...
Authors:Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P.
Deposit date:2024-01-18
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Cryo-EM structure of human NTCP-Bulevirtide complex
To Be Published
4NJN
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BU of 4njn by Molmil
Crystal Structure of E.coli GlpG at pH 4.5
Descriptor: Rhomboid protease GlpG
Authors:Dickey, S.W, Baker, R.P, Cho, S, Urban, S.
Deposit date:2013-11-11
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity.
Cell(Cambridge,Mass.), 155, 2013
4NJP
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BU of 4njp by Molmil
Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity
Descriptor: Rhomboid protease GlpG
Authors:Dickey, S.W, Baker, R.P, Cho, S, Urban, S.
Deposit date:2013-11-11
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity.
Cell(Cambridge,Mass.), 155, 2013
6RYK
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BU of 6ryk by Molmil
Crystal structure of the ParB-like protein PadC
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Altegoer, F, Bange, G.
Deposit date:2019-06-10
Release date:2020-01-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches.
Cell, 179, 2019
5AFW
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BU of 5afw by Molmil
Assembly of methylated LSD1 and CHD1 drives AR-dependent transcription and translocation
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, ...
Authors:Metzger, E, Willmann, D, McMillan, J, Petroll, K, Metzger, P, Gerhardt, S, vonMaessenhausen, A, Schott, A.K, Espejo, A, Eberlin, A, Wohlwend, D, Schuele, K.M, Schleicher, M, Perner, S, Bedford, M.T, Dengjel, J, Flaig, R, Einsle, O, Schuele, R.
Deposit date:2015-01-26
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Assembly of Methylated Kdm1A and Chd1 Drives Androgen Receptor-Dependent Transcription and Translocation.
Nat.Struct.Mol.Biol., 23, 2016
2NRF
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BU of 2nrf by Molmil
Crystal Structure of GlpG, a Rhomboid family intramembrane protease
Descriptor: Protein GlpG
Authors:Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y.
Deposit date:2006-11-02
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.
Nat.Struct.Mol.Biol., 13, 2006

 

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