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1DLH
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BU of 1dlh by Molmil
CRYSTAL STRUCTURE OF THE HUMAN CLASS II MHC PROTEIN HLA-DR1 COMPLEXED WITH AN INFLUENZA VIRUS PEPTIDE
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CLASS II HISTOCOMPATIBILITY ANTIGEN (HLA-DR1) (ALPHA CHAIN), ...
Authors:Stern, L.J.
Deposit date:1994-02-15
Release date:1994-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide.
Nature, 368, 1994
5ISZ
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BU of 5isz by Molmil
Crystal structure of LS01-TCR/M1-HLA-A*02 complex
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Stern, L.J, Selin, L.K, Song, I.
Deposit date:2016-03-15
Release date:2017-03-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8(+) T cell epitope.
Nat. Struct. Mol. Biol., 24, 2017
5JHD
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BU of 5jhd by Molmil
Crystal structure of LS10-TCR/M1-HLA-A*02 complex
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
Authors:Stern, L.J, Selin, L.K, Song, I.
Deposit date:2016-04-20
Release date:2017-03-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8(+) T cell epitope.
Nat. Struct. Mol. Biol., 24, 2017
6MGQ
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BU of 6mgq by Molmil
ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, Phosphinic inhibitor DG014, ...
Authors:Stern, L.J, Maben, Z.
Deposit date:2018-09-14
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Nat Commun, 12, 2021
6NCA
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BU of 6nca by Molmil
HLA-A2 (A*02:01) bound to a peptide from the Epstein-Barr virus BRLF1 protein
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
Authors:Stern, L.J, Selin, L.K, Song, I.Y.
Deposit date:2018-12-11
Release date:2019-10-23
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3.300001 Å)
Cite:CDR3 alpha drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection.
Plos Pathog., 15, 2019
1AQD
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BU of 1aqd by Molmil
HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE
Descriptor: HLA-A2, HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN
Authors:Murthy, V.L, Stern, L.J.
Deposit date:1997-07-28
Release date:1998-01-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding.
Structure, 5, 1997
1AF4
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BU of 1af4 by Molmil
CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN ANHYDROUS DIOXANE
Descriptor: 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG
Authors:Schmitke, J.L, Stern, L.J, Klibanov, A.M.
Deposit date:1997-03-21
Release date:1997-06-16
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BFK
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BU of 1bfk by Molmil
CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN 40% ACETONITRILE
Descriptor: ACETONITRILE, CALCIUM ION, SUBTILISIN CARLSBERG
Authors:Schmitke, J.L, Stern, L.J, Klibanov, A.M.
Deposit date:1998-05-21
Release date:1998-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents.
Biochem.Biophys.Res.Commun., 248, 1998
1BE8
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BU of 1be8 by Molmil
TRANS-CINNAMOYL-SUBTILISIN IN WATER
Descriptor: CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, SUBTILISIN CARLSBERG
Authors:Schmitke, J.L, Stern, L.J, Klibanov, A.M.
Deposit date:1998-05-20
Release date:1998-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BFU
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BU of 1bfu by Molmil
SUBTILISIN CARLSBERG IN 20% DIOXANE
Descriptor: 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG
Authors:Schmitke, J.L, Stern, L.J, Klibanov, A.M.
Deposit date:1998-05-22
Release date:1998-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents.
Biochem.Biophys.Res.Commun., 248, 1998
1BE6
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BU of 1be6 by Molmil
TRANS-CINNAMOYL-SUBTILISIN IN ANHYDROUS ACETONITRILE
Descriptor: ACETONITRILE, CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, ...
Authors:Schmitke, J.L, Stern, L.J, Klibanov, A.M.
Deposit date:1998-05-20
Release date:1998-10-14
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
6EA4
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BU of 6ea4 by Molmil
ERAP2 bound to Aryl Sulfonamide Uncompetitive Inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Maben, Z, Stern, L.J.
Deposit date:2018-08-02
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of human ER aminopeptidase 1 bound to aryl sulfonamide inhibitor.
To Be Published
5UV6
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BU of 5uv6 by Molmil
Crystal structure of human Opioid Binding Protein/Cell Adhesion Molecule Like (OPCML)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Opioid-binding protein/cell adhesion molecule, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Birtley, J.R, Stern, L.J, Gabra, H, Zanini, E.
Deposit date:2017-02-19
Release date:2018-03-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.65002 Å)
Cite:Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.
Nat Commun, 10, 2019
5J44
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BU of 5j44 by Molmil
Crystal structure of the Secreted Extracellular protein A (SepA) from Shigella flexneri
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Serine protease SepA autotransporter
Authors:Birtley, J.R, Stern, L.J, McCormick, B, Maldonado-Contreras, A.
Deposit date:2016-03-31
Release date:2017-04-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.912 Å)
Cite:Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation.
Gut Microbes, 8, 2017
7KEI
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BU of 7kei by Molmil
DQA1*01:02/DQB1*06:02 in complex with a hemagglutinin peptide from the H1N1 pandemic flu virus.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HA peptide from 2009 H1N1 pandemic flu virus., ...
Authors:Birtley, J.R, Stern, L.J, Mellins, E.D, Jiang, W.
Deposit date:2020-10-10
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of DQA1*01:02/DQB1*06:02 in complex with a flu peptide.
To Be Published
6DIG
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BU of 6dig by Molmil
Crystal structure of DQA1*01:02/DQB1*06:02 in complex with a hypocretin peptide
Descriptor: 13-mer peptide: ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-GLY-LYS, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Birtley, J.R, Stern, L.J, Mellins, E.D, Jiang, W.
Deposit date:2018-05-23
Release date:2019-05-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:In vivo clonal expansion and phenotypes of hypocretin-specific CD4+T cells in narcolepsy patients and controls.
Nat Commun, 10, 2019
1SEB
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BU of 1seb by Molmil
COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
Descriptor: ENDOGENOUS PEPTIDE MODEL, POLY-ALA, ENTEROTOXIN TYPE B, ...
Authors:Jardetzky, T.S, Brown, J.H, Gorga, J.C, Stern, L.J, Urban, R.G, Chi, Y.I, Stauffacher, C, Strominger, J.L, Wiley, D.C.
Deposit date:1995-11-26
Release date:1996-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.
Nature, 368, 1994
1SJH
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BU of 1sjh by Molmil
HLA-DR1 complexed with a 13 residue HIV capsid peptide
Descriptor: Enterotoxin type C-3, GAG polyprotein, HLA class II histocompatibility antigen, ...
Authors:Zavala-Ruiz, Z, Strug, I, Walker, B.D, Norris, P.J, Stern, L.J.
Deposit date:2004-03-03
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proc.Natl.Acad.Sci.Usa, 101, 2004
1T5X
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BU of 1t5x by Molmil
HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2
Descriptor: 15-mer peptide fragment of Regulatory protein MIG1, Enterotoxin type C-3, HLA class II histocompatibility antigen, ...
Authors:Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J.
Deposit date:2004-05-05
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
1T5W
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BU of 1t5w by Molmil
HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR)
Descriptor: 15-mer peptide fragment of Regulatory protein MIG1, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J.
Deposit date:2004-05-05
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
1I5I
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BU of 1i5i by Molmil
THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN
Descriptor: (GAMMA-B) CRYSTALLIN
Authors:Zarutskie, J.A, Asherie, N, Pande, J, Pande, A, Lomakin, J, Lomakin, A, Ogun, O, Stern, L.J, King, J.A, Benedek, G.B.
Deposit date:2001-02-27
Release date:2001-03-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
J.Mol.Biol., 314, 2001
2IPK
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BU of 2ipk by Molmil
Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2
Descriptor: Enterotoxin type C-3, HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine), ...
Authors:Nguyen, T.T, Stern, L.J.
Deposit date:2006-10-12
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Nat.Chem.Biol., 3, 2007
4OV5
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BU of 4ov5 by Molmil
Structure of HLA-DR1 with a bound peptide with non-optimal alanine in the P1 pocket
Descriptor: HLA class I histocompatibility antigen, A-2 alpha chain, HLA class II histocompatibility antigen, ...
Authors:Trenh, P, Yin, L, Stern, L.J.
Deposit date:2014-02-20
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide.
J.Biol.Chem., 289, 2014
4P46
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BU of 4p46 by Molmil
J809.B5 Y31A TCR bound to IAb3K
Descriptor: 3K Peptide,H-2 class II histocompatibility antigen, A beta chain, H-2 class II histocompatibility antigen, ...
Authors:Stadinski, B.D, Huseby, E.S, Trenh, P, Stern, L.J.
Deposit date:2014-03-11
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.
J Immunol., 192, 2014
4P5T
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BU of 4p5t by Molmil
14.C6 TCR complexed with MHC class II I-Ab/3K peptide
Descriptor: H-2 class II histocompatibility antigen, A-B alpha chain, Human nkt tcr beta chain, ...
Authors:Trenh, P, Stadinski, B, Huseby, E.S, Stern, L.J.
Deposit date:2014-03-19
Release date:2014-05-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.263 Å)
Cite:Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.
J Immunol., 192, 2014

 

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