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Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in complex with the cytosolic domain of its cognate anti-sigma factor RskA
Descriptor:	Anti-sigma-K factor RskA, CADMIUM ION, ECF RNA polymerase sigma factor SigK
Authors:	Shukla, J.K, Gopal, B.
Deposit date:	2013-11-25
Release date:	2014-01-22
Last modified:	2014-04-16
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structural basis for the redox sensitivity of the Mycobacterium tuberculosis SigK-RskA sigma-anti-sigma complex Acta Crystallogr.,Sect.D, 70, 2014

Mouse Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor
Descriptor:	(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-5-methoxy-6-[(3R,4R,5S)-4-oxidanyl-5-(4-pyrimidin-5-yl-1,2,3-triazol-1-yl)oxan-3-yl]sulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-ol, Galectin-3
Authors:	Ghosh, K, Kumar, A.
Deposit date:	2020-11-06
Release date:	2021-06-23
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors. J.Med.Chem., 64, 2021

Human Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor
Descriptor:	(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-5-methoxy-6-[(3R,4R,5S)-4-oxidanyl-5-(4-pyrimidin-5-yl-1,2,3-triazol-1-yl)oxan-3-yl]sulfanyl-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-3-ol, CHLORIDE ION, Galectin-3, ...
Authors:	Ghosh, K, Kumar, A.
Deposit date:	2020-11-06
Release date:	2021-06-23
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.08 Å)
Cite:	Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors. J.Med.Chem., 64, 2021

Structure of human Galectin-3 CRD in complex with monosaccharide inhibitor
Descriptor:	(2~{S},3~{R},4~{R},5~{R},6~{R})-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-[2-[5-chloranyl-2-(trifluoromethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,5-diol, Galectin-3
Authors:	Shukla, J, Raman, S, Ghosh, K.
Deposit date:	2022-04-01
Release date:	2022-10-12
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (0.98 Å)
Cite:	Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3. J.Med.Chem., 65, 2022