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7BCS
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BU of 7bcs by Molmil
ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation.
Descriptor: (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
7SP5
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BU of 7sp5 by Molmil
Crystal Structure of a Eukaryotic Phosphate Transporter
Descriptor: PHOSPHATE ION, Phosphate transporter, nonyl beta-D-glucopyranoside
Authors:Stroud, R.M, Pedersen, B.P, Kumar, H, Waight, A.B, Risenmay, A.J, Roe-Zurz, Z, Chau, B.H, Schlessinger, A, Bonomi, M, Harries, W, Sali, A, Johri, A.K, Finer-Moore, J.
Deposit date:2021-11-02
Release date:2021-11-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a eukaryotic phosphate transporter.
Nature, 496, 2013
7BCQ
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BU of 7bcq by Molmil
ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation.
Descriptor: 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
7BCT
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BU of 7bct by Molmil
ASCT2 in the presence of the inhibitor ERA-21 in the outward-open conformation.
Descriptor: Neutral amino acid transporter B(0)
Authors:Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A.
Deposit date:2020-12-21
Release date:2021-09-22
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc.Natl.Acad.Sci.USA, 118, 2021
6NFJ
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BU of 6nfj by Molmil
Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide
Descriptor: Beta-klotho, Fibroblast growth factor 19, Nanobody 30
Authors:Kuzina, E, Schlessinger, J, Lee, S.
Deposit date:2018-12-20
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8T6U
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BU of 8t6u by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to Dipyridamole
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2023-06-18
Release date:2023-09-13
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
8T6V
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BU of 8t6v by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatostilbene-2,2'-Disulfonic Acid (DIDS)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ...
Authors:Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2023-06-18
Release date:2023-09-13
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
6U5L
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BU of 6u5l by Molmil
Structure of human ULK4 in complex with an inhibitor
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine, ...
Authors:Khamrui, S, Lazarus, M.B.
Deposit date:2019-08-28
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
J.Am.Chem.Soc., 142, 2020
8FVZ
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BU of 8fvz by Molmil
PiPT Y150A
Descriptor: CITRATE ANION, PHOSPHATE ION, Phosphate transporter
Authors:Gupta, M, Finer-Moore, J, Stroud, R.M.
Deposit date:2023-01-20
Release date:2024-01-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Roles of PiPT residues in phosphate binding and transport tested by mutagenesis
To be published
3HD6
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BU of 3hd6 by Molmil
Crystal Structure of the Human Rhesus Glycoprotein RhCG
Descriptor: Ammonium transporter Rh type C, octyl beta-D-glucopyranoside
Authors:Gruswitz, F, Chaudhary, S, Ho, J.D, Pezeshki, B, Ho, C.-M, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2009-05-06
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Function of human Rh based on structure of RhCG at 2.1 A.
Proc.Natl.Acad.Sci.USA, 107, 2010
7TY4
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BU of 7ty4 by Molmil
Cryo-EM structure of human Anion Exchanger 1
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, ...
Authors:Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2022-02-11
Release date:2023-08-16
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
7TY8
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BU of 7ty8 by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to Niflumic Acid
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, ...
Authors:Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2022-02-11
Release date:2023-08-16
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
7TYA
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BU of 7tya by Molmil
Cryo-EM structure of human Anion Exchanger 1 modified with Diethyl Pyrocarbonate (DEPC)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, ...
Authors:Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2022-02-11
Release date:2023-08-16
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
7TY7
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BU of 7ty7 by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to Bicarbonate
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ...
Authors:Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2022-02-11
Release date:2023-08-16
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
7TY6
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BU of 7ty6 by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ...
Authors:Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2022-02-11
Release date:2023-08-16
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
4K1C
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BU of 4k1c by Molmil
VCX1 Calcium/Proton Exchanger
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, IODIDE ION, ...
Authors:Waight, A.B, Pedersen, B.P, Stroud, R.M, Center for Structures of Membrane Proteins (CSMP)
Deposit date:2013-04-04
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for alternating access of a eukaryotic calcium/proton exchanger.
Nature, 499, 2013

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