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1AM4
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BU of 1am4 by Molmil
COMPLEX BETWEEN CDC42HS.GMPPNP AND P50 RHOGAP (H. SAPIENS)
Descriptor: CDC42HS, MAGNESIUM ION, P50-RHOGAP, ...
Authors:Rittinger, K, Walker, P, Gamblin, S.J, Smerdon, S.J.
Deposit date:1997-06-22
Release date:1998-07-15
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature, 388, 1997
1TX4
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BU of 1tx4 by Molmil
RHO/RHOGAP/GDP(DOT)ALF4 COMPLEX
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, P50-RHOGAP, ...
Authors:Rittinger, K, Walker, P.A, Smerdon, S.J, Gamblin, S.J.
Deposit date:1997-07-29
Release date:1998-09-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue.
Nature, 389, 1997
1QJB
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BU of 1qjb by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
Descriptor: 14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
Authors:Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJA
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BU of 1qja by Molmil
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
Descriptor: 14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
Authors:Rittinger, K, Budman, J, Xu, J, Volinia, S, Cantley, L.C, Smerdon, S.J, Gamblin, S.J, Yaffe, M.B.
Deposit date:1999-06-23
Release date:1999-09-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
5FEY
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BU of 5fey by Molmil
TRIM32 RING
Descriptor: E3 ubiquitin-protein ligase TRIM32, ZINC ION
Authors:Rittinger, K, Esposito, D, Koliopoulos, M.G.
Deposit date:2015-12-17
Release date:2016-05-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Embo J., 35, 2016
5FER
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BU of 5fer by Molmil
Complex of TRIM25 RING with UbcH5-Ub
Descriptor: E3 ubiquitin/ISG15 ligase TRIM25, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D1, ...
Authors:Rittinger, K, Koliopoulos, M.G, Esposito, D.
Deposit date:2015-12-17
Release date:2016-05-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity.
Embo J., 35, 2016
7ZJ3
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BU of 7zj3 by Molmil
Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate
Descriptor: Polyubiquitin-C, Tripartite motif-containing protein 2, Ubiquitin-conjugating enzyme E2 D1, ...
Authors:Esposito, D, Garza-Garcia, A, Dudley-Fraser, J, Rittinger, K.
Deposit date:2022-04-08
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Nat Commun, 13, 2022
1E96
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BU of 1e96 by Molmil
Structure of the Rac/p67phox complex
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, NEUTROPHIL CYTOSOL FACTOR 2 (NCF-2) TPR DOMAIN, ...
Authors:Lapouge, K, Smith, S.J.M, Walker, P.A, Gamblin, S.J, Smerdon, S.J, Rittinger, K.
Deposit date:2000-10-10
Release date:2000-11-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the TPR domain of p67phox in complex with Rac.GTP.
Mol.Cell, 6, 2000
8BVL
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BU of 8bvl by Molmil
Crystal structure of the IBR-RING2 domain of HOIL-1
Descriptor: RanBP-type and C3HC4-type zinc finger-containing protein 1, ZINC ION
Authors:Stieglitz, B, Koliopoulos, M.G, Rittinger, K.
Deposit date:2022-12-04
Release date:2023-01-18
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural basis for ubiquitylation by HOIL-1.
Front Mol Biosci, 9, 2022
4EMO
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BU of 4emo by Molmil
Crystal structure of the PH domain of SHARPIN
Descriptor: Sharpin
Authors:Stieglitz, B, Haire, L.F, Dikic, I, Rittinger, K.
Deposit date:2012-04-12
Release date:2012-05-02
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold.
J.Biol.Chem., 287, 2012
5NT1
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BU of 5nt1 by Molmil
Complex of influenza A NS1 effector domain with TRIM25 coiled coil
Descriptor: E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:Koliopoulos, M.G, Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
5NT2
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BU of 5nt2 by Molmil
Complex of influenza A NS1 with TRIM25 coiled coil domain
Descriptor: E3 ubiquitin/ISG15 ligase TRIM25, Non-structural protein 1
Authors:Koliopoulos, M.G, Rittinger, K.
Deposit date:2017-04-27
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4.259 Å)
Cite:Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Nat Commun, 9, 2018
6EYR
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BU of 6eyr by Molmil
Crystal structure of the salmonella effector SseK3
Descriptor: Type III secretion system effector protein
Authors:Esposito, D, Rittinger, K.
Deposit date:2017-11-13
Release date:2018-02-28
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the glycosyltransferase activity of theSalmonellaeffector SseK3.
J. Biol. Chem., 293, 2018
6EYT
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BU of 6eyt by Molmil
Crystal structure of the Salmonella effector SseK3 in complex with UDP-GlcNAc and Manganese
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, IODIDE ION, MANGANESE (II) ION, ...
Authors:Esposito, D, Rittinger, K.
Deposit date:2017-11-13
Release date:2018-02-28
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural basis for the glycosyltransferase activity of theSalmonellaeffector SseK3.
J. Biol. Chem., 293, 2018
6GZY
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BU of 6gzy by Molmil
HOIP-fragment5 complex
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase RNF31, SODIUM ION, ...
Authors:Johansson, H, Tsai, Y.C.I, Fantom, K, Chung, C.W, Martino, L, House, D, Rittinger, K.
Deposit date:2018-07-05
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.
J. Am. Chem. Soc., 141, 2019
1OW3
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BU of 1ow3 by Molmil
Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rho-GTPase-activating protein 1, ...
Authors:Graham, D.L, Lowe, P.N, Grime, G.W, Marsh, M, Rittinger, K, Smerdon, S.J, Gamblin, S.J, Eccleston, J.F.
Deposit date:2003-03-28
Release date:2003-05-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MgF(3)(-) as a Transition State Analog of Phosphoryl Transfer
Chem.Biol., 9, 2002
1NG2
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BU of 1ng2 by Molmil
Structure of autoinhibited p47phox
Descriptor: Neutrophil cytosolic factor 1
Authors:Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K.
Deposit date:2002-12-16
Release date:2003-05-20
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of phosphorylation-induced activation of the NADPH oxidase
Cell(Cambridge,Mass.), 113, 2003
1OV3
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BU of 1ov3 by Molmil
Structure of the p22phox-p47phox complex
Descriptor: Flavocytochrome b558 alpha polypeptide, Neutrophil cytosol factor 1
Authors:Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K.
Deposit date:2003-03-25
Release date:2003-05-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis of phosphorylation-induced activation of the NADPH oxidase
Cell(Cambridge,Mass.), 113, 2003
4LJO
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BU of 4ljo by Molmil
Structure of an active ligase (HOIP)/ubiquitin transfer complex
Descriptor: E3 ubiquitin-protein ligase RNF31, IMIDAZOLE, Polyubiquitin-C, ...
Authors:Rana, R.R, Stieglitz, B, Koliopoulos, M.G, Morris-Davies, A.C, Christodoulou, E, Howell, S, Brown, N.R, Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.564 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
4LJP
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BU of 4ljp by Molmil
Structure of an active ligase (HOIP-H889A)/ubiquitin transfer complex
Descriptor: E3 ubiquitin-protein ligase RNF31, Polyubiquitin-C, ZINC ION
Authors:Rana, R.R, Stieglitz, B, Koliopoulos, M.G, Morris-Davies, A.C, Christodoulou, E, Howell, S, Brown, N.R, Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
4LJQ
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BU of 4ljq by Molmil
Crystal structure of the catalytic core of E3 ligase HOIP
Descriptor: E3 ubiquitin-protein ligase RNF31, ZINC ION
Authors:Stieglitz, B, Rana, R.R, Koliopoulos, M.G, Morris-Davies, A.C, Christodoulou, E, Howell, S, Brown, N.R, Rittinger, K.
Deposit date:2013-07-05
Release date:2013-10-16
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.
Nature, 503, 2013
2AK5
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BU of 2ak5 by Molmil
beta PIX-SH3 complexed with a Cbl-b peptide
Descriptor: 8-residue peptide from a signal transduction protein CBL-B, Rho guanine nucleotide exchange factor 7
Authors:Jozic, D, Cardenes, N, Deribe, Y.L, Moncalian, G, Hoeller, D, Groemping, Y, Dikic, I, Rittinger, K, Bravo, J.
Deposit date:2005-08-03
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cbl promotes clustering of endocytic adaptor proteins.
Nat.Struct.Mol.Biol., 12, 2005
2VRW
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BU of 2vrw by Molmil
Critical structural role for the PH and C1 domains of the Vav1 exchange factor
Descriptor: PROTO-ONCOGENE VAV, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, ZINC ION
Authors:Rapley, J, Tybulewicz, V, Rittinger, K.
Deposit date:2008-04-16
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crucial Structural Role for the Ph and C1 Domains of the Vav1 Exchange Factor.
Embo Rep., 9, 2008
6GGO
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BU of 6ggo by Molmil
Crystal structure of Salmonella zinc metalloprotease effector GtgA
Descriptor: Bacteriophage virulence determinant, CHLORIDE ION, ZINC ION
Authors:Jennings, E, Esposito, D, Rittinger, K, Thurston, T.
Deposit date:2018-05-03
Release date:2018-08-29
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B.
J. Biol. Chem., 293, 2018
6GGR
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BU of 6ggr by Molmil
Crystal structure of Salmonella zinc metalloprotease effector GtgA in complex with p65
Descriptor: Bacteriophage virulence determinant, CHLORIDE ION, Transcription factor p65
Authors:Jennings, E, Esposito, D, Rittinger, K, Thurston, T.
Deposit date:2018-05-03
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-kappa B.
J. Biol. Chem., 293, 2018

 

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