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1E3O
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BU of 1e3o by Molmil
Crystal structure of Oct-1 POU dimer bound to MORE
Descriptor: 5'-D(*AP*TP*GP*CP*AP*TP*GP*AP*GP*GP*A)-3', 5'-D(*TP*CP*CP*TP*CP*AP*TP*GP*CP*AP*T)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1
Authors:Remenyi, A, Tomilin, A, Pohl, E, Schoeler, H, Wilmanns, M.
Deposit date:2000-06-20
Release date:2001-11-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping
Mol.Cell, 8, 2001
1HF0
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BU of 1hf0 by Molmil
Crystal structure of the DNA-binding domain of Oct-1 bound to DNA as a dimer
Descriptor: DNA 5'-D(*CP*AP*CP*AP*TP*TP*TP*GP*AP*AP*AP*GP*GP* CP*AP*AP*AP*TP*GP*GP*AP*G)-3', DNA 5'-D(*CP*TP*CP*CP*AP*TP*TP*TP*GP*CP*CP*TP*TP* TP*CP*AP*AP*AP*TP*GP*TP*G)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1
Authors:Remenyi, A, Tomilin, A, Pohl, E, Scholer, H.R, Wilmanns, M.
Deposit date:2000-11-27
Release date:2001-11-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential Dimer Activities of the Transcription Factor Oct-1 by DNA-Induced Interface Swapping
Mol.Cell, 8, 2001
1GT0
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BU of 1gt0 by Molmil
Crystal structure of a POU/HMG/DNA ternary complex
Descriptor: 5'-D(*AP*TP*CP*CP*CP*AP*TP*TP*AP*GP* CP*AP*TP*CP*CP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3', 5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*TP*TP* GP*GP*AP* TP*GP*CP*TP*AP*AP*TP*GP*GP*GP*A)-3', OCTAMER-BINDING TRANSCRIPTION FACTOR 1, ...
Authors:Remenyi, A, Wilmanns, M.
Deposit date:2002-01-09
Release date:2003-01-30
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers
Genes Dev., 17, 2003
2B9F
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BU of 2b9f by Molmil
Crystal structure of non-phosphorylated Fus3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9J
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BU of 2b9j by Molmil
Crystal structure of Fus3 with a docking motif from Far1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cyclin-dependent kinase inhibitor FAR1, MAGNESIUM ION, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9I
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BU of 2b9i by Molmil
Crystal structure of Fus3 with a docking motif from Msg5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2B9H
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BU of 2b9h by Molmil
Crystal structure of Fus3 with a docking motif from Ste7
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitogen-activated protein kinase FUS3, ...
Authors:Remenyi, A, Good, M.C, Bhattacharyya, R.P, Lim, W.A.
Deposit date:2005-10-11
Release date:2006-01-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Mol.Cell, 20, 2005
2F49
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BU of 2f49 by Molmil
Crystal structure of Fus3 in complex with a Ste5 peptide
Descriptor: MAGNESIUM ION, Mitogen-activated protein kinase FUS3, STE5 peptide, ...
Authors:Remenyi, A.
Deposit date:2005-11-22
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
Science, 311, 2006
6TCA
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BU of 6tca by Molmil
Phosphorylated p38 and MAPKAPK2 complex with inhibitor
Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide
Authors:Sok, P, Remenyi, A.
Deposit date:2019-11-05
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Structure, 28, 2020
3TEI
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BU of 3tei by Molmil
Crystal structure of human ERK2 complexed with a MAPK docking peptide
Descriptor: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1
Authors:Gogl, G, Remenyi, A.
Deposit date:2011-08-15
Release date:2012-08-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove.
Sci.Signal., 5, 2012
4QSY
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BU of 4qsy by Molmil
SHP2 SH2 domain in complex with GAB1 peptide
Descriptor: GRB2-associated-binding protein 1, Tyrosine-protein phosphatase non-receptor type 11
Authors:Gogl, G, Remenyi, A.
Deposit date:2014-07-06
Release date:2015-07-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling
To be Published
6ZQS
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BU of 6zqs by Molmil
Crystal structure of double-phosphorylated p38alpha with ATF2(83-102)
Descriptor: 2-[(2,4-difluorophenyl)amino]-7-{[(2R)-2,3-dihydroxypropyl]oxy}-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one, Cyclic AMP-dependent transcription factor ATF-2, Mitogen-activated protein kinase 14
Authors:Kirsch, K, Sok, P, Poti, A.L, Remenyi, A.
Deposit date:2020-07-10
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Nat Commun, 11, 2020
6ZR5
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BU of 6zr5 by Molmil
Crystal structure of JNK1 in complex with ATF2(19-58)
Descriptor: Cyclic AMP-dependent transcription factor ATF-2, MAGNESIUM ION, Mitogen-activated protein kinase 8, ...
Authors:Kirsch, K, Zeke, A, Remenyi, A.
Deposit date:2020-07-10
Release date:2020-11-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38.
Nat Commun, 11, 2020
3QBV
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BU of 3qbv by Molmil
Structure of designed orthogonal interaction between CDC42 and nucleotide exchange domains of intersectin
Descriptor: Cell division control protein 42 homolog, GUANOSINE-5'-DIPHOSPHATE, Intersectin-1
Authors:Kapp, G.T, Remenyi, A, Lim, W.A, Kortemme, T.
Deposit date:2011-01-14
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.
Proc.Natl.Acad.Sci.USA, 109, 2012
3FZE
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BU of 3fze by Molmil
Structure of the 'minimal scaffold' (ms) domain of Ste5 that cocatalyzes Fus3 phosphorylation by Ste7
Descriptor: Protein STE5
Authors:Good, M.C, Tang, G, Singleton, J, Remenyi, A, Lim, W.A.
Deposit date:2009-01-25
Release date:2009-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.
Cell(Cambridge,Mass.), 136, 2009
4NIF
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BU of 4nif by Molmil
Heterodimeric structure of ERK2 and RSK1
Descriptor: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1, ...
Authors:Gogl, G, Remenyi, A.
Deposit date:2013-11-06
Release date:2014-11-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex
Proc.Natl.Acad.Sci.USA, 112, 2015
2XS0
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BU of 2xs0 by Molmil
Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3, ...
Authors:Barkai, T, Toeoroe, I, Garai, A, Remenyi, A.
Deposit date:2010-09-24
Release date:2011-09-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
Sci. Signal, 5, 2012
2XRW
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BU of 2xrw by Molmil
Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Descriptor: GLYCEROL, MITOGEN-ACTIVATED PROTEIN KINASE 8, NUCLEAR FACTOR OF ACTIVATED T-CELLS, ...
Authors:Barkai, T, Toeoroe, I, Garai, A, Remenyi, A.
Deposit date:2010-09-23
Release date:2011-09-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
Sci. Signal, 5, 2012
2Y8O
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BU of 2y8o by Molmil
Crystal structure of human p38alpha complexed with a MAPK docking peptide
Descriptor: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6, MITOGEN-ACTIVATED PROTEIN KINASE 14
Authors:Barkai, T, Garai, A, Toeroe, I, Remenyi, A.
Deposit date:2011-02-08
Release date:2012-02-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
Sci. Signal, 5, 2012
2Y9Q
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BU of 2y9q by Molmil
Crystal structure of human ERK2 complexed with a MAPK docking peptide
Descriptor: MAP KINASE-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1, MITOGEN-ACTIVATED PROTEIN KINASE 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Barkai, T, Garai, A, Toeroe, I, Remenyi, A.
Deposit date:2011-02-16
Release date:2012-02-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Specificity of Linear Motifs that Bind to a Common Mitogen-Activated Protein Kinase Docking Groove.
Sci. Signal, 5, 2012
7OPO
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BU of 7opo by Molmil
RSK2 N-terminal kinase domain in complex with ORF45
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein ORF45, Ribosomal protein S6 kinase alpha-3
Authors:Sok, P, Remenyi, A, Alexa, A, Poti, A.
Deposit date:2021-06-01
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Nat Commun, 13, 2022
7OPM
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BU of 7opm by Molmil
Phosphorylated ERK2 in complex with ORF45
Descriptor: 1-[4-(hydroxymethyl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-[(1S)-1-phenylethyl]urea, GLYCEROL, Mitogen-activated protein kinase 1, ...
Authors:Sok, P, Remenyi, A, Alexa, A, Poti, A.
Deposit date:2021-06-01
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
Nat Commun, 13, 2022
7PPL
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BU of 7ppl by Molmil
SHP2 catalytic domain in complex with IRS1 (625-639) phosphopeptide (pTyr-632, pSer-636)
Descriptor: ETHANOL, GLYCEROL, Insulin receptor substrate 1, ...
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
7PPM
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BU of 7ppm by Molmil
SHP2 catalytic domain in complex with IRS1 (889-901) phosphopeptide (pSer-892, pTyr-896)
Descriptor: GLYCEROL, Insulin receptor substrate 1, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022
7PPN
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BU of 7ppn by Molmil
SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195)
Descriptor: GLYCEROL, T-cell-specific surface glycoprotein CD28, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11
Authors:Sok, P, Zeke, A, Remenyi, A.
Deposit date:2021-09-14
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling.
Nat Commun, 13, 2022

 

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